Abstract:Objective To investigate the using of antihypertensive drug and the blood pressure control effect of hypertension patients in rural areas of Northern areas in Jiangsu Province,to screen out cost-effective treatment regimen,and to provide evidences for guiding the rational selection of antihypertensive drugs in rural areas.Methods The data of hypertension patients in four standardized management points in rural areas of Northern Jiangsu were statistically analyzed,and the commonly used antihypertensive treatment regimens were selected.Patients at high risk of hypertension who were treated with five categories of antihypertensive drugs and/or Chinese traditional medicine/compound preparation,and did not change or stop their medication plan by themselves during the follow-up were selected as study subjects.Medication regimens and blood pressure control rates of patients at high risk of hypertension were compared.Results There were 3 009 eligible patients with high risk of hypertension in the hypertension cohort study,and there were nine common drug treatment regimen,including compound preparation,ACEI,CCB,CCB + ACEI,Diuretic,CCB+compound preparation,compound preparation+Traditional Chinese medicine,ACEI+compound preparation,and Diuretic+CCB.There were significant differences in the blood pressure control rate after one year of standardized management in high-risk patients treated with nine drug regiments (χ2=30.11,P<0.01 ).The result of Scheffé confidence interval showed that the blood pressure control rate in the using of CCB was significantly higher than that of ACEI(0.015 4,0.256 0).Conclusions Among the nine common drug regimens,the blood pressure control rate of Diuretics+CCB was the highest,and the rate in the using of CCB was higher than that of ACEI.CCB drugs were recommended as the first choice,or adopt the compound with CCB drugs as the core prescription for patients with high risk of hypertension in rural areas in Northern Jiangsu Province.