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投稿时间：2020-08-04 网络发布日期：2021-04-20
投稿时间：2020-08-04 网络发布日期：2021-04-20
中文摘要: 目的 通过检测不同影像学分期的糖皮质激素诱导性股骨头坏死(SONFH)患者血清中1型纤溶酶原激活物抑制剂(PAI-1)水平变化,探讨血清PAI-1水平与SONFH的关系,以及PAI-1在不同X线影像学分期SONFH的意义。方法 选取2018年6月至2019年5月于徐州医科大学附属邳州医院就诊的SONFH患者75例作为观察组,国际骨循环学会(ARCO)分期:Ⅱ期25例、Ⅲ期25例、Ⅳ期25例,并随机选取75例健康体检者作为对照组。使用ELISA 法检测两组对象血清PAI-1水平。结果 观察组血清PAI-1水平显著高于对照组［(21.87±2.39) mg/L vs (12.52±1.22) mg/L,P<0.05］;但不同影像学分期的SONFH患者间,血清PAI-1水平差异无统计学意义(P>0.05)。股骨头未塌陷与塌陷SONFH患者间,血清PAI-1水平差异无统计学意义(P>0.05)。结论 SONFH患者血清PAI-1水平较正常人群明显增高,可做为SONFH临床诊断和治疗的一项参考指标。但是在SONFH患者中,PAI-1水平与X线影像学分期无明显相关,且与股骨头塌陷与否无关。
Abstract:Objective To investigate the relationship between serum plasminogen activator inhibitor 1(PAI-1) and imaging of steroid (glucocorticoid)-induced onecrosis of femoral head (SONFH) in different X-ray imaging stages and their significance.
Methods A total of 75 SONFH patients treated at Pizhou Hospital Affiliated to Xuzhou Medical University from June 2018 to May 2019 were selected as observation group,including 25 cases of stage Ⅱ,25 cases of stage Ⅲ and 25 cases of stage Ⅳ based on Association Research Circulation Osseous(ARCO) staging.During the same period,75 healthy persons were randomly selected as control group.The serum PAI-1 levels were detected by enzyme-linked immunosorbent assay (ELISA) and compared between two groups.
Results The serum PAI-1 level in observation group was significantly higher than that in control group ［(21.87±2.39) mg/L vs (12.52±1.22) mg/L,P<0.05］.However,there were no significant differences in serum PAI-1 level among SONFH patients with different imaging stages(including no collapse and collapse of femoral head) (all P>0.05).
Conclusions In the patients with SONFH,the serum PAI-1 level increases significantly,which can be used as a reference index for clinical diagnosis and treatment of SONFH.However,PAI-1 level is not obviously correlated with X-ray imaging staging and femoral head collapse or not.
keywords: Necrosis of femoral head,steroid(glucocorticoid)-induced Plasminogen activator inhibitor 1 Imaging Association Research Circulation Osseous Staging
文章编号： 中图分类号： 文献标志码：B
基金项目:徐州医科大学校级科研基金(2018KJ23)
附件
| 作者 | 单位 |
| 王国强1,2 | 1.徐州医科大学附属医院影像科,江苏 徐州 221003；2.徐州医科大学附属邳州医院CT室,江苏 徐州 221300 |
| 胡春峰1 | 1.徐州医科大学附属医院影像科,江苏 徐州 221003 |
| Author Name | Affiliation |
| WANG Guo-qiang*,HU Chun-feng | *Department of Imaging,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221003,China |
引用文本：
王国强,胡春峰.糖皮质激素诱导性股骨头坏死患者影像学分期与血清PAI-1水平的关系[J].中国临床研究,2021,34(4):506-508.
王国强,胡春峰.糖皮质激素诱导性股骨头坏死患者影像学分期与血清PAI-1水平的关系[J].中国临床研究,2021,34(4):506-508.