Abstract:Objective To investigate the application of vacuum sealing drainage (VSD) technique combined with dynamic monitoring of procalcitonin (PCT) in chronic refractory wounds (CRW). Methods Ninety patients with CRW treated from August 2018 to April 2020 were selected as the research objects and randomly divided into observation group and control group(n=45,each).VSD was performed in control group,and VSD combined with dynamic monitoring of PCT was conducted in observation group.The curative effect,therapeutic index,antibiotic usage,hospitalization expense and serum inflammatory factor level were compared between two groups. Results The curative effect in observation group was significantly better than that in control group (u=2.218,P=0.027).Compared with control group,the time for wound surface to enter into the red stage was significantly earlier,the number of dressing changes was significantly less,and the hospital stay was significantly shorter in observation group (P<0.05,P<0.01).At 7 days after admission,the levels of interferon γ (IFN-γ),interleukin 6(IL-6),leukocytes and high sensitivity C-reactive protein (hs-CRP) in observation group were significantly higher than those in control group (P<0.05,P<0.01).Compared with control group,the constituent ratios of combination of two or more antibiotics and upgraded antibiotics and the cost of antibiotics in observation group significantly decreased,and the course of drug use was significantly shortened (P<0.05,P<0.01).Compared with control group,the cost of examination increased,but other expenses,drug costs and total hospitalization costs decreased significantly in observation group (P<0.05,P<0.01). Conclusions VSD combined with dynamic monitoring of PCT can improve the curative effect,reduce the inflammatory response,optimize the use of antibiotics,and reduce the cost of hospitalization in the treatment of CRW.