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中国临床研究:2021,34(3):354-357
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丙酸倍氯米松结合硫酸沙丁胺醇雾化治疗支气管肺炎
(1.苏州大学附属无锡九院儿科,江苏 无锡 214062;2.无锡市儿童医院儿呼吸科,江苏 无锡 214023)
Effect of beclomethasone propionate combined with salbutamol sulfate nebulization in the treatment of bronchopneumonia
摘要
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投稿时间:2020-09-10   网络发布日期:2021-03-20
中文摘要: 目的 研究丙酸倍氯米松结合硫酸沙丁胺醇雾化治疗支气管肺炎的效果及患儿发病的危险因素。方法 选取2019年3月至2020年2月治疗的120例支气管肺炎患儿作为研究对象,按照随机分组原则,将以上患儿随机分为对照组以及观察组,每组患儿60例,两组患儿均采取对症治疗及硫酸沙丁胺醇雾化治疗,观察组患儿在此基础上联合使用丙酸倍氯米松,两组患儿均治疗7d。比较两组患儿的治疗效果、肺功能、骨代谢指标、临床症状改善情况以及不良反应之间的差异。结果 观察组患儿的治疗效果显著高于对照组,差异有统计学意义(P<0.05);经过治疗后,两组患儿的FEV、FEV1以及FEV1%均显著升高,且观察组患儿的FEV、FEV1以及FEV1%显著高于对照组(P<0.05);治疗前后,两组患儿的血钙、血磷以及碱性磷酸酶之间的差异无统计学意义(P>0.05);观察组患儿的发热消失时间、咳嗽消失时间、肺部罗音消失时间、住院时间显著低于对照组(P<0.05);两组患儿治疗期间的腹泻、皮疹、心率加快之间的差异无统计学意义(P>0.05)。结论 丙酸倍氯米松结合硫酸沙丁胺醇雾化治疗支气管肺炎的效果显著。
Abstract:Objective To investigate the efficacy of beclomethasone propionate combined with salbutamol sulfate nebulization for the treatment of bronchopneumonia and risk factors for morbidity in children. Methods A total of 120 children with bronchopneumonia treated in our hospital from March 2019 to February 2020 were selected as disease group,and they were divided into control group and observation group randomly (n=60,each).Symptomatic treatment and nebulization of salbutamol sulphate were adopted in control group and observation group for 7 days,based on which beclomethasone propionate was combined in the observation group.Differences in treatment efficacy,lung function,bone metabolic indexes,clinical symptom improvement,and adverse effects between the two groups of children were compared. Results Children in the observation group had a significantly higher treatment response rate than those in the control group (91.67% vs 78.33%,χ2=4.182,P<0.05).After treatment,FEV,FEV1 as well as FEV1% were significantly higher in both child groups,and these in the observation group were significant higher than those in the control group (P<0.05).Before and after treatment,there was no statistically significant difference in S-Ca,S-P as well as ALP between the observation group and control group (P>0.05).Time to disappearance of fever,disappearance of cough,disappearance of pulmonary rales,and hospital stay were significantly lower in the observation group than in the control group (P<0.05).There was no significant difference in the incidence of adverse reactions (such as diarrhea,rash,rapid heart rate) between the two groups during treatment (P>0.05). Conclusion Beclomethasone propionate combined with salbutamol sulphate nebulisation for the treatment of bronchopneumonia is highly effective.
文章编号:     中图分类号:    文献标志码:B
基金项目:江苏省医学创新团队(CXTDB2017016)
附件
引用文本:
司琴,马静,华琰,等.丙酸倍氯米松结合硫酸沙丁胺醇雾化治疗支气管肺炎[J].中国临床研究,2021,34(3):354-357.

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