本文已被：浏览 738次 下载 385次
投稿时间：2020-09-06 网络发布日期：2021-03-20
投稿时间：2020-09-06 网络发布日期：2021-03-20
中文摘要: 目的 探讨2型糖尿病(T2DM)患者中血尿酸(SUA)水平与非酒精性脂肪肝病(NAFLD)的关系。方法 对合肥市第一人民医院2010年1月至2016年12月收治的1 808例T2DM患者进行横断面研究,通过腹部B超诊断 NAFLD,分为非 NAFLD组和 NAFLD组,其中NAFLD组患者668例,非NAFLD组患者1 140例。按照SUA四分位数分为4组(Q1～Q4),分析SUA水平与代谢指标之间的关系。结果 本研究人群中NAFLD的发生率为36.9%。Q1、Q2、Q3和Q4四组间年龄、病程、体质指数（BMI）、收缩压（SBP）、舒张压（DBP）、三酰甘油（TG）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨甲酰转移酶（AST）、γ-谷氨酰转肽酶（γ-GT）、血清肌酐（SCr）、空腹血糖（FPG）、空腹C肽（FCP）、高密度脂蛋白胆固醇（HDL-C）、总胆红素（TBIL）差异均具有统计学意义（P<0.05），总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）差异无统计学意义（P>0.05）。在男性中 NAFLD的患病率随SUA水平的逐步升高（Q1、Q2、Q3、Q4）逐渐增加(13.07％,32.50％,41.71％,49.75％,P<0.01)。Spearman相关分析显示了SUA与其他代谢指标之间的相关性,在两种性别中SUA 水平与 BMI、SBP、TG、ALT、AST、γ-GT、SCr、FCP均显著正相关(P<0.01),与FPG、HDL-C、TBIL呈负相关(P<0.01，P<0.05)。多元 Logistic回归分析结果显示,BMI、TG、ALT、FCP、SUA是 NAFLD 的影响因素(P<0.01，P<0.05)。结论 T2DM男性患者中SUA与NAFLD密切相关,是NAFLD的独立危险因素。
中文关键词: 2型糖尿病 尿酸 非酒精性脂肪肝；性别；血糖；血脂
Abstract:Objective To investigate the relationship between serum uric acid (SUA) level and nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Methods A cross-sectional study was conducted in 1 808 patients with T2DM from January 2010 to December 2016.By abdominal ultrasound diagnosis,there were 668 patients in NAFLD group and 1 140 patients in non NAFLD group.According to the quartile of SUA level,the patients were divided into four groups (Q1-Q4),and the relationship between SUA level and metabolic indicators was analyzed. Results The incidence of NAFLD was 36.9%.There were significant differences in age, disease duration,body mass index (BMI), systolic blood pressure (SBP),diastolic blood pressure (DBP), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST),γ-glutamyl transpeptidase (γ-GT),serum creatinine (SCr), fasting plasma glucose (FPG), fasting C-peptide (FCP),high density liptein cholesterol (HDL-C) and total bilirubin (TBIL) (P<0.05),while there was no significant difference in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P>0.05) among the Q1, Q2, Q3 and Q4 group.The prevalence of NAFLD in men was 13.07%,32.50%,41.71% and 49.75% in group Q1,Q2,Q3 and Q4,respectively (P<0.01).Spearman correlation analysis showed SUA level was significantly positively correlated with BMI,SBP,TG,ALT,AST,γ-GT,SCr and FCP (P<0.01) and was negatively correlated with FPG,HDL-C and TBIL in both genders (P<0.05).Multiple Logistic regression analysis revealed that BMI,TG,ALT,FCP and SUA were the influencing factors for NAFLD(P<0.05). Conclusion SUA is closely related to NAFLD in male patients with T2DM and is an independent risk factor for NAFLD.
keywords: Type 2 diabetes mellitus Uric acid Nonalcoholic fatty liver disease Gender Plasma glucose Blood lipids
文章编号： 中图分类号： 文献标志码：A
基金项目:国家自然科学基金 (30840106)
| Author Name | Affiliation |
| XU Yun-yun,LIU Shang-quan | Department of Endocrinology,the Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230000,China |
引用文本：
徐云云,刘尚全.2型糖尿病患者血尿酸与非酒精性脂肪肝疾病的相关性[J].中国临床研究,2021,34(3):294-298.
徐云云,刘尚全.2型糖尿病患者血尿酸与非酒精性脂肪肝疾病的相关性[J].中国临床研究,2021,34(3):294-298.