Abstract:Objective To explore the application effect of different concentration of nalbuphine in children′s gastroscopy and its [JP2]impacts on adverse events.Methods A total of 255 children undergoing painless gastroscopy in Shanghai Children′s[JP] Medical Center from February 2018 to December 2019 were randomly divided into group A(0.10 mg/kg),group B(0.15 mg/kg) and group C(0.20 mg/kg) according to the concentrations of nalbuphine( n=85,each).Before anesthesia(T0),at gastroscope insertion(T1) and at gastroscope withdrawal(T2),heart rate(HR),mean arterial pressure(MAP) and pulse oxygen saturation(SpO2) were measured and compared among three groups.The anesthesia effect,the total amount of propofol used,the time of gastroscopy,the consciousness time,the discharge time and the occurrence of intraoperative and postoperative adverse events were recorded and compared among three groups.Results There were no significant differences in HR,MAP and SpO2 at T0,T1 and T2 among the three groups( P>0.05).The total dosage of propofol and the recovery time in group A were statistically higher than those in group B and group C( P<0.05),but there were no significant differences between group B and group C( P>0.05).The discharge time in group C was significantly longer than that in group A and group B( P<0.05),and there was no significant difference between group B and group C( P>0.05）.The incidence of respiratory depression,nausea,vomiting and vertigo in group C was significantly higher than those in group A and group B( P<0.05),and there was no significant difference in it between group A and group B( P>0.05).Conclusion The different concentrations of nalbuphine have significant effects on the use of propofol in children gastroscopy,and nalbuphine at doses of 0.15 mg/kg combined with a suitable dose of propofol has good anesthetic effect and safety.