Abstract:Objective To systematically evaluate the relationship between low bone mineral density(osteopenia and osteoporsis) and the risk of stroke and death. Methods CNKI database,Wanfang database,VIP Chinese periodical service platform,PubMed,Embase and Cochrane Library databases for cohort studies on low bone mineral density,stroke risk and death risk from the establishment of the database to February 2020 were searched by computer. According to the inclusion and exclusion criteria, the literatures were independently screened, the data were extracted, and after the quality evaluation, the data were analyzed by Stata 14.0 software and implemented by two examiners. Results A total of 11 articles (all in English,5 from the United States,1 from Sweden,and 5 from China) were included,with a total of 76 667 subjects.Meta-analysis results showed that osteoporosis and osteopenia can significantly increase the risk of stroke (HR=1.69,95%CI=1.28-2.25;HR=1.24,95%CI=1.01-1.52) and the risk of all-cause death (HR=1.86,95%CI=1.23-2.80;HR=1.21,95%CI=1.15-1.27).And osteopenia can significantly increase the risk of stroke in women (HR=1.37,95%CI=1.06-1.77). Conclusion Low bone mineral density is associated with an increased risk of stroke and all-cause death.