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投稿时间：2020-02-14 网络发布日期：2020-12-20
投稿时间：2020-02-14 网络发布日期：2020-12-20
中文摘要: 目的 观察白头翁汤加减方口服治疗轻、中度溃疡性结肠炎急性发作的临床疗效。方法 选取2017年1月至2019年1月就诊的60例诊断为轻、中度溃疡性结肠炎急性发作(湿热内蕴证)患者，按照随机数字表法，将患者随机分为对照组和试验组各30例;对照组患者予以柳氮磺胺吡啶肠溶片口服，1 g/次，3次/d;试验组患者在对照组基础上，加以白头翁汤加减方口服，3次/d，1天1剂;两组患者均治疗4周，观察两组患者前后症状积分，炎症因子肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-8，以及结肠镜评分、黏膜组织评分、Mayo指数评分。结果 (1)治疗后两组患者主症及次症症状积分、TNF-α、hs-CRP、IL-8、结肠镜评分、黏膜组织评分、Mayo 指数评分与治疗前比较，均有好转，差异有统计学意义(P<0.05);(2)治疗后两组对比，试验组好转程度明显优于对照组，差异有统计学意义(P<0.05);(3)试验组总有效率93.3%，对照组总有效率80.0%，试验组疗效优于对照组，差异有统计学意义(Z=2.075，P<0.05)。结论 白头翁汤加减方口服，能够改善轻、中度溃疡性结肠炎急性发作临床症状、结肠镜下组织形态以及机体炎症反应，提高临床疗效。
Abstract:Objective To observe the clinical effect of Baitouweng decoction in the treatment of acute active stage of mild to moderate ulcerative colitis. Methods Sixty patients with acute episode of mild-to-moderate ulcerative colitis (damp- heat syndrome) were randomly divided into control group and experimental group (n=30, each) according to the random number table method.The sulfasalazine enteric coated tablets (1 g/time, 3 times/day) were orally given in both groups, and modified Baitouweng decoction (3 times one day, one dose per day) was added in experimental group.After treatment for 4 weeks, the symptom scores, inflammatory factors, tumor necrosis factor (TNF)-α, high sensitivity C-reactive protein (hs-CRP), interleukin-8(IL-8), colonoscopy score, mucosal tissue score and Mayo endoscopic score were observed and compared. Results After treatment, main symptom and secondary symptom score, levels of TNF-α, CRP and IL-8, colonoscopy score, mucosal tissue score and Mayo score were statistically better than those before treatment in two groups (P<0.05) and were significantly better in experimental group than those in control group (P<0.05).The total effective rate in experimental group was statistically higher than that in control group (Z=2.075, P<0.05). Conclusion Baitouweng decoction can improve the clinical symptoms, tissue morphology under colonoscopy and body inflammatory reaction in patients with acute active stage of mild to moderate ulcerative colitis.
文章编号： 中图分类号：R256.34，R574.62 文献标志码：B
基金项目:陕西省中医药管理局课题(JCPT050);陕西中医药大学课题(2016PY02)
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引用文本：
雷彪，冯文哲，石鹏，牛魁，柴小琴.白头翁汤加减治疗轻中度溃疡性结肠炎急性发作临床观察[J].中国临床研究,2020,33(12):1681-1683,1687.
雷彪，冯文哲，石鹏，牛魁，柴小琴.白头翁汤加减治疗轻中度溃疡性结肠炎急性发作临床观察[J].中国临床研究,2020,33(12):1681-1683,1687.