Abstract:Objective To investigate the clinical effect of ultrasound-guided thoracolumbar fascia combined with facet joint optimal block in patients with non-specific low back pain (NLBP). Methods A total of 63 patients with NLBP diagnosed from May 2018 to June 2019 were randomly divided into ultrasound-guided facet joint block group (group A), ultrasound-guided thoracolumbar fascia block group (group B), and ultrasound-guided facet joint+thoracolumbar fascia block group (group C), with 21 cases in each group.Visual analogue scale (VAS) and Japanese Orthopaedic Association (JOA) scores were observed before treatment, 1 week, 1 month and 3 months after treatment, and adverse reactions such as nerve injury, puncture site infection, toxic reaction, drug allergy, nausea and vomiting were recorded. Results After 1 week, 1 month and 3 months of treatment, VAS score of the three groups was lower than that before treatment, and JOA score was higher than that before treatment (P<0.01).One week after treatment, VAS score decreased in the order of group A→ group B→ group C (P<0.05).At 1 and 3 months after treatment, VAS score of group C was lower than that of group A and group B (P<0.01).One week after treatment, JOA score of group B and group C was higher than that of group A (P<0.05, P<0.01).One month after treatment, JOA score increased in the order of group A→ group B→ group C (P<0.05, P<0.01).3 months after treatment, JOA score of group C was higher than that of group A and group B (P<0.01).No nerve injury, puncture site infection, toxic reaction, drug allergy, nausea and vomiting complications occurred in the three groups. Conclusion Ultrasound guided thoracolumbar fascia combined with facet joint optimization block was effective in NLBP patients without obvious adverse reactions.