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投稿时间：2020-04-05 网络发布日期：2020-11-20
投稿时间：2020-04-05 网络发布日期：2020-11-20
中文摘要: 目的 探讨超声弹性应变率比值法联合血清血管内皮生长因子(VEGF)、原癌基因CerbB-2检测对乳腺结节良恶性的鉴别价值。方法 选取2017年12月至2019年12月130例存在乳腺可疑结节患者为研究对象，经病理证实,其中良性病变60例,恶性病变70例。对比不同病变患者血清VEGF、CerbB-2水平、超声弹性应变率；ROC曲线分析超声弹性应变率联合血清VEGF、CerbB-2检测对乳腺结节良恶性的鉴别效能，比较恶性病变不同病理特征患者血清VEGF、CerbB-2水平的差异；Pearson相关分析超声弹性应变率与恶性结节患者血清VEGF、CerbB-2水平的相关性。结果 恶性病变患者血清VEGF、CerbB-2水平及超声弹性应变率比值高于良性病变患者(P<0.01);联合检测鉴别诊断乳腺病变良恶性的ROC曲线下面积为0.855,大于血清VEGF(0.799)、CerbB-2(0.777)、超声弹性应变率(0.778)单独诊断;联合检测鉴别诊断的敏感度为78.57%,特异度为78.33%。不同分化程度、有无淋巴结转移恶性病变患者血清VEGF、CerbB-2水平相比差异有统计学意义(P<0.01);恶性结节患者超声弹性应变率与血清VEGF、CerbB-2水平呈正相关(r=0.527,0.556,P<0.05)。 结论 乳腺结节良恶性患者超声弹性应变率比值和血清VEGF、CerbB-2水平不同,联合检测鉴别病变类型具有较高应用价值,可为临床完善相关机制提供参考依据。
Abstract:Objective To explore the value of ultrasound elastic strain rate combined with serum vascular endothelial growth factor (VEGF) and proto-oncogene CerbB-2 detection in the differentiation of breast nodules.Methods From December 2017 to December 2019,130 patients with suspicious breast nodules were selected,including 60 benign lesions and 70 malignant lesions.The serum VEGF,CerbB-2 levels and ultrasonic elastic strain rate in patients with different lesions were compared.The ratio of ultrasonic elastic strain rate combined with serum VEGF and CerbB-2 detection in the diagnosis of benign and malignant breast nodules by ROC curve.The differences of serum VEGF and CerbB-2 levels in patients with different pathological features of malignant lesions were compared.The correlation between ultrasonic elastic strain rate and serum VEGF and CerbB-2 levels of patients with malignant nodules was analyzed by Pearson correlation.Results Serum VEGF and CerbB-2 levels and ultrasound elastic strain rate of patients with malignant lesions were higher than those with benign lesions ( P<0.01);the area under the ROC curve for differential diagnosis of benign and malignant breast lesions with combined detection was 0.855,which was greater than that diagnosed separately by serum VEGF (0.799) and CerbB-2 (0.777),ultrasonic elastic strain rate (0.778);the sensitivity and the specificity of differential diagnosis was 78.57%,78.33%.There were significant differences in serum VEGF and CerbB-2 levels in malignant lesions patients with different levels of differentiation,with or without lymph node metastasis ( P<0.01);ultrasound elastic strain rate was positively correlated with serum VEGF and CerbB-2 levels in patients with malignant nodules ( r=0.527,0.556, P<0.05).Conclusions The ultrasound elastic strain rate,serum VEGF and CerbB-2 levels are different in patients with benign and malignant breast nodules.Combined detection to identify lesion types has high application value,which can provide a reference for clinical improvement of related mechanisms.
keywords: Breast nodules Ultrasonic elastic strain rate Vascular endothelial growth factor CerbB-2 ROC curve Differential diagnosis
文章编号： 中图分类号： 文献标志码：A
基金项目:安徽省科学技术厅公益性研究联动计划项目(1704f0804050)
| Author Name | Affiliation |
| DUAN Geng-yong,HAN Lu,FANG Kai-feng | Department of Ultrasound,General Hospital of Wanbei Coal Electricity Group,Suzhou,Anhui 234000,China |
引用文本：
段更勇, 韩路, 方开峰.超声弹性应变率联合血清VEGF、CerbB-2检测对乳腺结节良恶性的鉴别价值[J].中国临床研究,2020,33(11):1481-1485.
段更勇, 韩路, 方开峰.超声弹性应变率联合血清VEGF、CerbB-2检测对乳腺结节良恶性的鉴别价值[J].中国临床研究,2020,33(11):1481-1485.