Abstract:Objective To observe the curative effect of botulinum toxin type A (BoNT-A) combined with task-oriented training on the recovery of upper limb function in patients with upper-limb spasticity(ULS) post-stroke. Methods A prospective study was conducted in 48 patients with early ULS post-stroke from January 2017 to October 2019.The patients were divided into control group (n=21,treated with conventional physical manipulation,physical therapy and acupuncture),observation group (n=16,treated with task-oriented occupational therapy based on the method in control group) and treatment group (n=11,treated with ultrasound-guided BoNT-A injection after evaluation on the basis of method in observation group before and after injection).The course of treatment was 8 weeks in three groups.Before and after treatment,modified Ashworth scale (MAS),assessment of upper limb motor recovery,WOLF motor function test (WMFT),modified Rankin scale,functional independence measure(FIM) were used to evaluate upper limb function,and modified Barthel index (MBI) was used to evaluate activities of daily living (ADL). Results There were statistical differences in MAS,assessment of upper limb motor recovery level,WMFT,FIM and MBI between pre-treatment and post-treatment in three groups (P<0.05,P<0.01).MAS of elbow flexor muscle groups and assessment of upper limb motor recovery level in treatment group were better than those in observation group and control group;modified Rankin scale,MBI and FIM in treatment group and observation group were better than those in control group;WMFT in treatment group was better than that in observation group (P<0.05,P<0.01). Conclusion In the treatment of ULS post-stroke,BoNT-A combined with task-oriented training can reduce upper limbs muscle tension,improve hand function and ADL of patients,and reduce the occurrence of sequelae.