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投稿时间：2019-05-21 网络发布日期：2020-09-20
投稿时间：2019-05-21 网络发布日期：2020-09-20
中文摘要: 目的 观察清肝化瘀、化痰通络剂联合松龄血脉康治疗肝热血瘀痰浊型高血压病患者的临床疗效。方法 选择2017年1月到2018年1月来诊高血压患者194例,随机分为治疗组98 例和对照组96例,治疗组予以清肝化瘀、化痰通络剂联合松龄血脉康治疗,对照组予以硝苯地平控释片治疗,统计分析两组患者24 h平均动脉压、血压变异性、中医证候积分等指标。结果 治疗后治疗组患者的24 h平均收缩压显著低于对照组(P<0.05),但两组患者的24 h平均舒张压之间差异无统计学意义(P>0.05)。治疗组患者的白天舒张压标准差显著低于对照组(P<0.05),但两组患者的白天收缩压标准差、夜间收缩压标准差、夜间舒张压标准差之间差异无统计学意义(P>0.05)。治疗组患者的24 h收缩压标准差显著低于对照组(P<0.05),但两组患者的24 h舒张压标准差之间差异无统计学意义(P>0.05)。治疗组患者的中医症候总积分显著低于对照组(P<0.05)。两组均未发生不良事件。结论 清肝化瘀、化痰通络剂联合松龄血脉康可有效降低 24 h 平均收缩压、减少血压变异性和改善症状。
Abstract:Objective To investigate the clinical efficacy of Qinggan Huayu, Huatan Tongluo agent combined with Songling Xuemaikang in the treatment of hypertension (syndrome of liver heat, blood stasis and phlegm turbidity). Methods A total of 194 hypertension patients who received treatment from January 2017 to January 2018 were selected and divided into treatment group (n=98) and control group (n=96).The treatment group was treated with Qinggan Huayu, Huatan Tongluo agent combined with Songling Xuemaikang, while the control group was treated with nifedipine controlled-release tablets.The 24-hour mean arterial pressure, blood pressure variability, and TCM syndrome score of the two groups were analyzed. Results After treatment, the 24hSBP of the treatment group was significantly lower than that of the control group (P<0.05), but there was no significant difference between the two groups in 24hDBP(P>0.05).The dSSD of the treatment group was significantly lower than that of the control group (P<0.05), but there was no significant difference between the two groups in dDSD, nSSD and nDSD (P>0.05).The 24hSSD, 24hDSD of the treatment group were significantly lower than that of the control group (P<0.05).The total score of TCM symptoms in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Qinggan Huayu, Huatan Tongluo agents combined with Songling Xuemaikang can effectively reduce 24 h mean systolic blood pressure, reduce blood pressure variability and improve symptoms.
keywords: Qinggan Huayu, Huatan Tongluo Songling Xuemaikang Hypertension Nifedipine Blood pressure variability
文章编号： 中图分类号： 文献标志码：B
基金项目:国家自然科学基金(81060288)
引用文本：
邱作成,其满古丽·斯地克,许红峰,等.清肝化瘀、化痰通络剂联合松龄血脉康治疗原发性高血压病[J].中国临床研究,2020,33(9):1246-1249.
邱作成,其满古丽·斯地克,许红峰,等.清肝化瘀、化痰通络剂联合松龄血脉康治疗原发性高血压病[J].中国临床研究,2020,33(9):1246-1249.