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投稿时间：2019-12-20 网络发布日期：2020-09-20
投稿时间：2019-12-20 网络发布日期：2020-09-20
中文摘要: 目的 探讨类风湿性关节炎(RA)合并糖尿病(DM)患者血糖水平变化及其对病情活动度的影响。方法 选择2015年6月至2019年5月收治RA合并DM患者90例为研究对象,根据其血糖水平分为观察组和对照组,每组45例。检测两组患者的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、C反应蛋白(CRP)、类风湿因子(RF)水平及红细胞沉降率(ESR),并评估类风湿关节炎病情活动评分(DAS28)。用Pearson相关性分析FBG、HbA1c与CRP、ESR、DAS28等的相关性。结果 观察组患者的FBG水平为(8.08±3.30)mmol/L,高于对照组患者的(6.72±2.10)mmol/L,差异有统计学意义(P<0.05);观察组患者的HbA1c水平为(8.30±2.50)%,高于对照组的(6.91±1.21)%,差异有统计学意义(P<0.01)。观察组患者的CRP、RF、ESR水平及DAS28评分分别为(39.89±15.35)mg/L、(36.78±8.56)IU/ml、(42.84±14.06)mm/h、(5.90±1.82)分,均高于对照组患者的(30.38±14.42)mg/L、(31.01±8.35)IU/ml、(28.23±10.08)mm/h、(4.16±1.11)分,差异均有统计学意义(P<0.01)。Pearson相关分析结果显示,FBG、HbA1c水平与病情活动度指标CRP、RF、ESR、DAS28等均呈显著正相关(P<0.01)。结论 RA合并DM患者血糖水平明显升高,且与病情活动度呈显著正相关,提示血糖水平变化会对RA合并DM患者的病情活动度产生影响,故在临床治疗中需控制患者血糖来缓解病情进展。
Abstract:Objective To investigate the change of blood glucose level in patients with rheumatoid arthritis(RA) complicated with diabetes mellitus (DM) and its influence on disease activity. Methods Ninety RA patients with DM treated from June 2015 to May 2019 were selected and divided into observation group and control group according to the blood glucose levels (n=45, each).The levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), C-reactive protein (CRP), rheumatoid factor (RF) and erythrocyte sedimentation rate (ESR) were detected, and the disease activity score-28 (DAS28) in RA was evaluated in two groups.Pearson correlation was used to analyze the associations of FBG and HbA1c with CRP, ESR and DAS28. Results The levels of FBG ［(8.08±3.30) mmol/L vs (6.72±2.10)mmol/L］ and HbA1c［(8.30±2.50)% vs (6.91±1.21)%］in observation group were statistically higher than those in control group (P<0.05, P<0.01).The levels of CRP, RF, ESR and DAS28 score were (39.89±15.35)mg/L, (36.78±8.56)IU/ml, (42.84±14.06) mm/h and 5.90±1.82, respectively, in observation group, and they were(30.38±14.42)mg/L, (31.01±8.35)IU/ml, (28.23±10.08)mm/h and 4.16±1.11, respectively, in control group, and there were statistical differences between two groups (all P<0.01).Pearson correlation analysis showed that FBG and HbA1c levels were positively correlated with disease activity indicators such as CRP, RF, ESR and DAS28 obviously (all P<0.01).Conclusion In RA patients complicated with DM, the level of blood glucose significantly increases and is positively correlated with the disease activity, suggesting that the change of blood glucose level can affect the disease activity in RA.Therefore, it is necessary to control the blood glucose of RA patients to alleviate the disease progression in clinical treatment.
文章编号： 中图分类号： 文献标志码：B
基金项目:山东省自然科学基金(ZR2017FH150)
| Author Name | Affiliation |
| YIN Yan-xu*, LIU Hua-xiang | *Department of Rheumatology, Qilu Hospital of Shandong University, Jinan, Shandong 250002, China |
引用文本：
尹延旭,刘花香.类风湿性关节炎合并糖尿病患者血糖水平变化及其对病情活动度的影响[J].中国临床研究,2020,33(9):1214-1216,1220.
尹延旭,刘花香.类风湿性关节炎合并糖尿病患者血糖水平变化及其对病情活动度的影响[J].中国临床研究,2020,33(9):1214-1216,1220.