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投稿时间：2019-10-26 网络发布日期：2020-07-20
投稿时间：2019-10-26 网络发布日期：2020-07-20
中文摘要: 目的 观察冠心病患者血清锌指样转录因子2(KLF2)、脂蛋白相关磷脂酶 A2(LP-PLA2)的变化,并分析其与冠状动脉(冠脉)狭窄程度的相关性。
方法 选取2017年9月至2018年10月收治的106例冠心病患者作为观察组,依据冠脉狭窄程度分为四个亚组(轻度组、中度组、重度组及完全闭塞组),依据冠脉病变支数分为三个亚组(单支组、双支组与多支组),并取同期106例健康体检者纳入对照组,比较不同冠脉狭窄程度亚组与不同冠脉病变支数亚组血清KLF2与LP-PLA2水平、Gensini积分,并分析血清KLF2、LP-PLA2水平与Gensini积分的相关性。
结果 血清KLF2:对照组>单支组>双支组>多支组;血清LP-PLA2:对照组<单支组<双支组<多支组;Gensini积分:单支组<双支组<多支组,总体比较和两两比较差异均有统计学意义(P<0.01,P<0.05)。血清KLF2:对照组>轻度组>中度组>重度组>完全闭塞组;血清LP-PLA2:对照组<轻度组<中度组<重度组<完全闭塞组;Gensini积分:轻度组<中度组<重度组<完全闭塞组,总体比较和两两比较差异均有统计学意义(P<0.01,P<0.05)。Pearson相关分析结果示,冠心病患者血清KLF2与Gensini积分呈负相关(r=-0.596,P<0.01),LP-PLA2与Gensini积分呈正相关性(r=0.478,P<0.05)。
结论 冠心病患者血清KLF2、LP-PLA2水平与冠脉狭窄程度存在显著相关性,其检测可为冠脉病变评估提供一定依据。
中文关键词: 冠心病 锌指样转录因子2 脂蛋白相关磷脂酶 A2 冠状动脉狭窄 Gensini积分
Abstract:Objective To observe the change of serum Krüppel-like factor 2 (KLF2) and lipoprotein-associated phospholipase A2 (LP-PLA2) in patients with coronary heart disease,and analyze the correlation between KLF2 and the degree of coronary stenosis.
Methods A total of 106 patients with coronary heart disease from September 2017 to October 2018 were selected as the observation group.According to the degree of coronary stenosis,they were divided into four subgroups (mild group,moderate group,severe group and complete occlusion group).According to the number of diseased coronary arteries,they were divided into three subgroups (single branch group,double branch group and multi branch group).And 106 healthy check up persons in the same period were included in the control group.The levels of serum KLF2,LP-PLA2 and Gensini score were compared between the subgroups with different degree of coronary stenosis and the subgroups with different number of diseased coronary arteries,and the correlation between the levels of serum KLF2,LP-PLA2 and Gensini score was analyzed.
Results Serum KLF2:control group>single branch group>double branch group>multi branch group;serum LP-PLA2:control groupmild group>moderate group>severe group>complete occlusion group;serum LP-PLA2:control groupConclusions There is a significant correlation between KLF2,LP-PLA2 and the degree of coronary stenosis in patients with coronary heart disease.The detection of KLF2 and LP-PLA2 could provide a basis for the evaluation of coronary lesions.
keywords: Coronary heart disease Krüppel-like factor 2 Lipoprotein-associated phospholipase A2 Degree of coronary stenosis Gensini score
文章编号： 中图分类号： 文献标志码：B
基金项目:四川省卫生和计划委员会课题(17PJ019)
附件
| Author Name | Affiliation |
| DI Yun-feng,LI De-cai,ZHANG Da-yong | Department of Cardiology,Sichuan Mianyang 404 Hospital,Mianyang,Sichuan 621000，China |
引用文本：
邸云峰,李德才,张大勇.血清锌指样转录因子2和脂蛋白相关磷脂酶A2水平与冠心病冠状动脉狭窄程度的相关性[J].中国临床研究,2020,33(7):952-954,958.
邸云峰,李德才,张大勇.血清锌指样转录因子2和脂蛋白相关磷脂酶A2水平与冠心病冠状动脉狭窄程度的相关性[J].中国临床研究,2020,33(7):952-954,958.