Abstract:Objective To explore the safety and effectiveness of endoscopic minimally invasive treatment of gastric submucosal tumor. Methods The clinical data of 152 patients with gastric submucosal tumor undergoing endoscopic minimally invasive surgery from February 2014 to February 2019 were analyzed retrospectively.The average diameter of tumor was (1.32±0.80) cm.Endoscopic submucosal dissection (ESD group) was performed in 139 cases,and endoscopic full-thickness resection (EFR group) was conducted in 13 cases. Results The total resection rate was 100%.The wound healed well without serious complications.In ESD group,there were 30 cases originated from the muscularis mucosa，57 cases from the submucosa,52 cases from the superficial layer of the intrinsic muscle,and the maximum tumor diameter was 4.5 cm.In EFR group,13 cases were all originated from the deep layer of intrinsic muscle and adhered to the serous layer,and the largest tumor diameter was 2.2 cm. There were no significant differences in the operation time［（46.43±17.32)min vs (48.92±20.50)min］,postoperative fluid feeding time［(2.12±1.13)d vs (2.50±1.52)d］,postoperative hospital stay［(5.41±2.22)d vs (5.73±1.99)d］ between ESD group and EFR group (all P>0.05). After discharge,the mean follow-up was 20 months(range from 6-38 months).No residual or recurrent cases were found. Conclusion In the treatment of gastric submucosal tumors,endoscopic minimally invasive resection is safe and effective,however,endoscopic full-thickness resection provides a broader prospect for patients.