Abstract:Objecitve To investigate the therapeutic effect of acupuncture and Fuling Zhuru Decoction on post-stroke depression (PSD) and its effect on 5-hydroxytryptamine (5-HT). Methods From January 2018 to January 2019, 96 patients with PSD admitted to the Department of encephalopathy were selected as the research objects.According to the treatment method, they were divided into two groups.The control group (n=48) was treated with conventional western medicine, and the observation group (n=48) was treated with acupuncture and syndrome differentiation combined with Fuling Zhuru Eecoction.The therapeutic effects of the two groups were analyzed, including Hamilton Depression Scale (HAMD), National Institute of Health Stroke Scale (NIHSS), Modified Barthel Index (MBI), norepinephrine(NE), dopamine(DA) and 5-hydroxytryptamine(5-HT) before and after treatment. Results The total effective rate in the observation group was significantly higher than that in the control group(93.75% vs 79.17%, P<0.05).After treatment, the scores of HAMD and NIHSS in the two groups decreased, and the scores of MBI increased (P<0.05).After treatment, the scores of HAMD and NIHSS in the observation group were lower than those in the control group, and the score of MBI was higher than those in the control group (all P<0.05).After treatment, the levels of NE, DA and 5-HT in the two groups increased significantly (P<0.05).After treatment, the levels of NE, DA and 5-HT in the observation group were higher than those in the control group (P<0.05). Conclusion Acupuncture combined with Fuling Zhuru Decoction has a significant effect in the treatment of PSD, which can significantly improve the level of 5-HT, improve the state of depression, promote the recovery of neural function, and enhance the ability of daily activities.