Abstract:Objective To investigate the efficacy and safety of vacuum sealing drainage (VSD) combined with alprostadil and epalrestat in the treatment of diabetic foot ulcers. Methods A total of 104 patients with diabetic foot treated from June 2017 to December 2018 were enrolled and were randomly divided into study group and control group (n=52, each). VSD was performed in control group, and VSD combined with alprostadil and epalrestat was given in study group. After treatment for 21 days, the wound healing rate, total effective rate, sensory conduction velocity, ankle brachial index(ABI), serum tumor necrosis factor-α(TNF-α), hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and adverse reactions were observed and compared between two groups. Results The wound healing rate (98.08% vs 84.62%, P=0.036) and total effective rate (92.31% vs 76.93%, P=0.030) in study group were significantly higher than those in control group. The sensory conduction velocity of common peroneal nerve, superficial peroneal nerve and tibial nerve and ABI statistically increased in study group compared with control group (all P<0.01). The serum levels of TNF-α, hs-CRP and IL-6 in study group were significantly lower than those in control group (all P<0.01). There were no obvious adverse reactions in two groups. Conclusion VSD combined with alprostadil and epalrestat has a good clinical effect in the treatment of diabetic foot ulcers, which can effectively reduce the inflammatory response, improve microcirculation and sensory conduction velocity safely.