Abstract:Objective To explore the effect of pit and fissure sealing combined with scientific dietary guidance on prevention of dental caries in children and its influence on children′s examination coordination.Methods A total of 100 children with dental caries treated from June 2017 to January 2018 were selected and randomly divided into control group and combined group (n=50,each).The pit and fissure closure was performed in two groups,and the scientific dietary guidance was added in combined group.The mean value of caries for treated children and visual analogue scale (VAS),recurrence rate of caries,proximal caries rate,sealant retention rate,treatment effect,cooperation rate and the complications during the prevention and treatment of caries were observed and compared between two groups after six month.Results The mean value of caries(0.65±0.10 vs 0.89±0.14),VAS(6.11±0.86 vs 8.03±1.02),recurrence rate of caries（4.00% vs 24.00%） and proximal caries rate（2.00% vs 20.00%）in combined group were significantly lower than those in control group after six months(P<0.01).The retention rate of sealant (94.00% vs 80.00%),the total effective rate (94.00% vs 80.00%) and the cooperation rate (96.00% vs 82.00%) in combined group were significantly higher than those in control group (P<0.05,P<0.01).The total incidence of complications such as pulpitis,drop rate of the sealant and periapical periodontitis in combined group was significantly lower than that in control group (2.00% vs 18.00%,P<0.01).Conclusion In the preventing and treating caries in children,the pit and fissure sealing combined with scientific dietary guidance has significant effect and can effectively reduce the incidences of recurrence rate,proximal caries and complications with high degree of cooperation.