Abstract:Objective To study the value of contrastenhanced ultrasonography (CEUS) in evaluating the efficacy of radiotherapy and chemotherapy in patients with advanced cervical cancer.Methods A total of 76 patients with advanced cervical cancer from October 2016 to July 2018 were selected as study subjects.All patients were treated with chemotherapy combined with threedimensional conformal radiotherapy (3DCRT) and were divided into effective group(n=61) and ineffective group(n=15) according to the therapeutic effect.Before and after 4 cycles of chemotherapy,CEUS examinations were performed,the accuracy of CEUS in diagnosis of tumor inactivation was analyzed with pathological diagnosis as gold standard,and CEUS parameters were compared between two groups.Results After 4 cycles of chemotherapy,there were 36 cases of complete remission(CR),25 cases of partial remission(PR),10 cases of stable disease(SD),5 cases of disease progression(PD).The effective rate was 80.26% (61/76).After treatment,the tumor diameter was significantly smaller than that before treatment ［(13.72±3.21) mm vs (38.19±4.32) mm,t=39.636,P=0.000］.In 76 patients,86 tumor lesions were detected by CEUS with the accuracy of 91.86% (79/86).After treatment,the values of RT,PI and AUC decreased,and MTT,TP increased compared with those before treatment in effective group（P＜0.05）.There were no statistical differences in above values before and after treatment in ineffective group（P＞0.05）.Compared with ineffective group,the values of RT,PI,AUC decreased,and MTT,TP increased significantly in effective group（P＜0.05,P＜0.01）.Conclusion In the patients with advanced cervical cancer,radiotherapy and chemotherapy have good therapeutic effect,and CEUS examination before and after treatment can determine the tumor diameter and the change of tumor blood perfusion with high accuracy of tumor inactivation.CEUS examination can provide important data reference for clinical evaluation of radiotherapy and chemotherapy.