Abstract:Objective To investigate the clinical effect of fibular osteotomy combined with arthroscopic microfracture in the treatment of knee osteoarthritis.Methods A total of 100 patients with knee osteoarthritis treated from June 2015 to June 2018 were divided into observation group and control group(n=50,each).The fibular osteotomy combined with arthroscopic microfracture was conducted in observation group,while the arthroscopic microfracture alone was performed in control group.The changes in clinical symptoms were assessed by American Hospital for Special Surgery Score(HSS),and the degree of pain was evaluated by visual analogue scale (VAS) to compare the curative effects between two groups.The levels of matrix metalloproteinase (MMP)9,interleukin (IL)6 and tumour necrosis factorα(TNFα) in knee joint fluid were detected before and 12 months after operation,and the time of active flexion to 90° and straight leg elevation were recorded in both groups.Results The curative effect in observation group was slightly higher than that in control group（94.00% vs 82.00%,P>0.05）.After treatment,HSS increased,and VAS decreased significantly compared with those before treatment in two groups (P<0.05);HSS in observation group was higher than that in control group,and VAS was lower than that in control group statistically (P<0.05).After treatment,the levels of MMP9,IL6 and TNFα in the synovial fluid decreased significantly compared with those before treatment in two groups (P<0.05) and were statistically lower in observation group than those in control group（P<0.05）.The time for active flexion to 90° and straight leg elevation in observation group was significantly shorter than that in control group (P<0.01).Conclusion Fibular osteotomy combined with arthroscopic microfracture is effective in the treatment of knee osteoarthritis,which can improve joint function,relieve pain and promote joint recovery.