Abstract:Objective To discuss the relationship between osteoporosis(OP) and immunoregulatory cytokines in patients with rheumatoid arthritis (RA).Methods The clinical data,laboratory tests and serum samples of 115 patients with confirmed RA from January 2018 to February 2019 were collected.According to bone mineral density(BMD)value,RA patients were divided into RA accompanied by OP (RA with OP group,n=65) and RA without OP (RA without OP group,n=50).The levels of interleukin17(IL17),IL6,IL10,tumor necrosis factor(TNF)α,transforming growth factorβ1(TGFβ1),erythrocyte sedimentation rate(ESR),Creactive protein（CRP）,immunoglobulin (Ig)G,IgA,IgM were detected in two groups.Results The age,course of disease,tender joint count（TJC）,swollen joints count(SJC),history of fracture and history of glucocorticoid use in RA with OP group were significantly longer than those in RA without OP group (P<0.01).BMD values of each part in RA with OP group were significantly lower than those in RA without group (P<0.01).The BMD of lumbar vertebrae was significantly lower than that of hip joint in both groups (P<0.01).The levels of IL17,ESR,CPR and DAS28 (Disease Activity Score including a 28joint count)in RA with OP group were significantly higher,and IL10 was significantly lower than those in RA without OP group (P<0.01).Conclusions RA patients are prone to lumbar osteoporosis,and those who have used glucocorticoids are more likely to have osteoporosis and fracture.In RA patients with OP,age,course of disease,TJC,SJC,DAS28,levels of IL17 and CRP are generally high,and IL10 level is obviously low.The occurrence of OP in RA patients may be related to age,course of disease and corticosteroids use.Immunoregulatory cytokines possibly participate in the process of OP in RA,in which IL17 may be involved in the process of bone destruction,while IL10 may play a role in bone protection.