Abstract:Objective To investigate the clinical characteristics and biochemical indexes of malignant tumor patients with venous thrombosis as the first clinical manifestation,in order to promote the early diagnosis and treatment of malignant tumors. Methods The clinical data of 73 patients with venous thrombosis as the first clinical manifestation who received diagnosis and treatment in Shanxi Privincial People′s Hospital from January 2002 to November 2017 were analyzed retrospectively.After admission,the patients were diagnosed with venous thrombosis,and through comprehensive medical history inquiry,physical examination,basic laboratory examination,age- and gender-specific cancer screening,and more intensive cancer screening methods,all of them were finally confirmed as solid malignant tumor by pathology during hospitalization,and their clinical data were analyzed. [JP2]Results All the 73 patients were diagnosed as malignant tumor by pathology,including 28 cases of digestive system tumor,15 cases of neck and chest tumor,10 cases of urinary system tumor,8 cases of gynecological tumor,3 cases of mesenchymal tissue tumor,4 cases of hematological system tumor,5 cases of metastasis of unknown primary tumor,with the highest proportion of digestive system (38.4%).Among the 73 patients,57.5% were male,and 67.1% were over 50 years old.The level of albumin and cholinesterase in all patients was significantly lower than the normal reference values (all P<0.01),and the level of D-dimer was significantly higher than the normal reference value (P<0.01). Conclusion In the clinic,if there are patients with unknown causes of venous thrombosis,especially men,age ≥ 50 years old,deep venous thrombosis of the left lower extremity,significantly lower levels of albumin and cholinesterase,and significantly higher levels of D-dimer,we should be highly alert to the possibility of malignant tumors.