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投稿时间：2019-01-08 网络发布日期：2019-09-24
投稿时间：2019-01-08 网络发布日期：2019-09-24
中文摘要: 目的采用荟萃分析方法探讨血小板与淋巴细胞计数的比值(PLR)在食管癌预后中的预测意义。方法检索Pubmed、Embase、Cochrane Library、中国知网等常用数据库。同时提取了多因素分析的HR及其95％可信区间来作为总生存期（OS）和无疾病生存期（DFS）的效应量。采用Stata 12.0软件分析数据。使用纽卡斯尔特-渥太华量表评价文献质量。结果截至2018年12月1日,共纳入8篇文献,共计2 811例食管鳞癌患者。Meta分析结果发现，PLR升高与OS和DFS的缩短均有关系(HR=1.38,95％CI:1.24～1.55;HR=1.28,95％CI:1.06～1.55)。亚组分析得出了同样的结果。发表偏倚无统计学意义(P=0.796)。结论PLR的升高与食管鳞癌患者不良预后相关,且可作为食管鳞癌的独立预后指标。
中文关键词: 血小板与淋巴细胞比值 食管鳞癌 预后 荟萃分析
Abstract:Objective Using meta-analysis to explore the predictive significance of platelet-lymphocyte ratio (PLR) in the prognosis of esophageal squamous cell cancer(ESCC). Methods The common databases such as Pubmed,Embase,Cochrane Library,CNKI were searched,and hazard ratio (HR) and its 95% confidence interval(CI) by multivariate analysis were extracted as the effect indexes of overall survival(OS) and disease-free survival(DFS) of ESCC.Stata 12.0 software was used to analyze the data,and Newcastle-Ottawa scale was used to evaluate the quality of literature. Results As of December 1,2018,a total of 8 articles containing 2 811 patients with ESCC were enrolled in meta-analysis.The results showed that the increase of PLR was related to the shortening of OS (HR=1.38,95% CI:1.24-1.55) and DFS (HR=1.28,95% CI:1.06-1.55) of ESCC.Subgroup analysis on them yielded the same results.There was no significant difference in publication bias in meta-analyses(P=0.796). Conclusion The elevation of PLR is associated with poor prognosis of esophageal squamous cell carcinoma,and PLR can be served as an independent prognostic indicator.
文章编号： 中图分类号：R 735.1，R 446.11 文献标志码：A
基金项目:国家自然科学基金(81472234)
附件
| Author Name | Affiliation |
| LI Cheng-zhen,LI Wan-ying,GAO She-gan | Department of Oncology,The First Affiliated Hospital of Henan University of Science and Technology Luoyang,Henan 471003,China |
引用文本：
李成真,李婉莹,高社干.血小板与淋巴细胞比值对食管鳞癌预后预测作用的meta分析[J].中国临床研究,2019,32(9):1201-1205.
李成真,李婉莹,高社干.血小板与淋巴细胞比值对食管鳞癌预后预测作用的meta分析[J].中国临床研究,2019,32(9):1201-1205.