Abstract:Objective To investigate the application value of combined detection of serum ischemia modified albumin (IMA) and galectin-3 (Gal-3) in emergency patients with chest pain. Methods Ninety-two hospitalized patients with emergency chest pain suspected acute coronary syndrome (ACS) were selected.The blood specimens were collected within 2 hours of chest pain attack, and the contents of serum IMA and Gal-3 were measured by enzyme linked immunosorbent assay (ELISA).The patients were divided into 3 groups according to the results of ELISA combined with coronary angiography and intracoronary ultrasound:ACS group (n=38), stable angina pectoris (SAP) group (n=28) and non-coronal heart disease (NCHD) group (n=26).Level of serum IMA and Gal-3 were compared in three groups.The diagnostic value of combined detection of IMA and Gal-3 for ACS and SAP was observed. Results The levels of serum IMA and Gal-3 in ACS group were significantly higher than those in SAP group and NCHD group (P<0.01).The level of serum IMA in SAP group was significantly higher than that in NCHD group (P<0.05), while there was no significant difference in the level of serum Gal-3 between the two groups (P>0.05).The sensitivity, specificity, positive prediction value and negative prediction value of combined detection of IMA and Gal-3 were significantly higher than those for any single test of electrocardiogram, IMA and Gal-3 (P<0.05). Conclusion The combined detection of IMA and galectin-3 can improve the accuracy rate of diagnosis of coronary heart disease with emergency chest pain and have higher screening value for ACS before the increase of traditional markers of myocardial necrosis.Their combined detection can help to identify ACS, SAP and NCHD so as to achieve timely diagnosis and risk stratification for patients with chest pain.