Abstract:Objective To explore the changes of von Willebrand factor (vWF), factor Ⅷ coagulant activity (FⅧ:C) and related coagulant indexes in the patients with transient ischemic attack(TIA) and their clinical significance.? Methods A total of 60 TIA patients treated in neurology department from January 2015 to January 2016 were selected as study objects (observation group), and 60 healthy adults were served as control group. vWF, FⅧ:C and related coagulant indicators were detected and analyzed in two groups.? Results The levels of vWF [(215.51±24.11) U/L vs (120.99±20.34)U/L], FⅧ:C [(288.69±36.71) % vs(120.67±25.68)%], D- dimer, soluble fibrin monomer complex (SFMC) and other parameters were significantly higher in observation group than those in control group (all P＜0.05). However, there were no significant differences in activated partial thromboplastin time (APTT), prothrombin time (PT) and fibrinogen (FIB) between two groups(all P>0.05).? Conclusion The blood coagulation system is in a state of stress in TIA patients. Compared with healthy people, coagulation indexes of vWF, FⅧ:C, D-dimer and SFMC, etc. increase significantly, which have high significance in clinical diagnosis and treatment and may be involved in the pathogenesis of TIA.