Abstract:Objective To investigate the expression of Ki-67 protein in meningioma tissues and its relationship with patients′ clinic features.? Methods Sixty meningioma tissue specimens of surgical resection (meningioma group) and 18 normal meningeal tissue specimens excised by surgery (normal group) from January 2014 to April 2017 were collected. Immunohistochemical staining was used to detect the expression of Ki-67 protein in two kinds of tissue specimens and investigate its association with patients′ clinic features.? Results The positive expression rate of Ki-67 protein in meningioma tissues was significantly higher than that in normal group (73.33% vs 5.55%,? χ²=26.060, P<0.01). There was no significant relationship between Ki-67 protein expression in meningioma tissues and age, sex, tumor size, with or without dural tail sign (all P>0.05). Ki-67 protein expression rates in meningioma patients with appearance of peritumoral edema, stagesⅡand Ⅲ of World Health Organization (WHO) central nervous system tumor staging and with bone invasion were significantly higher than those in meningioma patients without peritumoral edema, with stage Ⅰof WHO central nervous system tumor staging and without bone invasion (all P<0.05).? Conclusion Ki-67 protein expression in meningioma tissues increases, and it has association with tumor staging, bone invasion and appearance of peritumoral edema.