Abstract:Objective To investigate the effect and significance of regular anti-epileptic therapy on peripheral blood T lymphocyte levels in epileptic patients. Methods A total of 300 cases of epileptic patients who received treatment in Chongqing Qianjiang National Hospital from September 2016 to August 2017 were divided into non-medication group and regular medication group according to whether they took anti-epilepsy drugs (150 cases each), and 150 cases of healthy examinees or volunteers at the same time were selected as control group. Flow cytometer was used to detect the level of CD3⁺, CD4⁺ and CD8⁺ T lymphocytes in peripheral blood of 3 groups, and the ratio of CD4⁺ and CD8⁺ was calculated. Turbidimetric inhibition immuno assay was used to detect the plasma immunoglobulin IgG, IgA and IgM level in of 3 groups′ patients. Results Compared to control group, the levels of CD8⁺ were higher in epileptic patients (non-medication group and regular medication group), and the level of CD3⁺, CD4⁺ and the ratio of CD4⁺ and CD8⁺ were lower in epileptic patients (P<0.05, P<0.01). Compared to the non-medication group, the level of CD3⁺, CD4⁺ and the ratio of CD4⁺ and CD8⁺ were higher in regular medication group, and the level of CD8⁺ in non-medication group was lower than that in regular medication group (P<0.05, P<0.01). The level of plasma IgA and IgG in epileptic patients were lower than those in control group (P<0.05, P<0.01). The level of IgA in regular medication group was higher than that in non-medication group (P<0.01). Conclusion Cellular and humoral immune dysfunction are generally exist in epileptic patients, and the regular use of anti-epileptic drugs can improve the imbalance of immune function.