Abstract:Objective To explore significance and expression of B-cell lymphoma-2 associated X protein (Bax), Myeloid cell leukemia-1 (Mcl-1) and Survivin in human glioma. Methods Immunohistochemical method was used to detect the expressions of Bax, Mcl-1 and Survivin proteins in 48 brain glioma tissue specimens（glioma group）and 48 brain tissue specimens from internal decompression surgery for traumatic brain injury (normal control group). All the specimens were collected from The First Affiliated Hospital of Shantou University Medical College. Results Positive expression rate of Bax protein in glioma group was significantly lower than that in normal control group（31.25% vs 70.83%, P<0. 01）, and positive expression rates of Mcl-1 and Survivin proteins in brain glioma tissues were significantly higher than those in normal control group（79.17% vs 39.58%, 0 vs 77.08%, all P<0. 01）. Positive expression rate of Bax protein in Ⅲ-Ⅳ grades brain glioma tissues was significantly lower than that in Ⅰ-Ⅱ grades brain tissues（18.18% vs 53.84%, P<0.01）, and the positive expression rates of Mcl-1 and Survivin in Ⅲ-Ⅳ grades brain glioma tissues were significantly higher than those in Ⅰ-Ⅱ grades brain tissues（90.91% vs 57.69%, 100.00% vs 50.00%, all P<0. 01）. In brain glioma, the expession of Bax was significantly negatively correlated with Mcl-1（r=-0. 532,P=0. 000）and Survivin（r=-0. 349, P=0. 000） respectively, while the expression of Mcl-1 was significantly positively correlated with Survivin（r=0.465,P=0. 000）. Conclusion Low expression of Bax and high expressions of Mcl-1 and Survivin are closely related to the malignant degree of glioma, and their joint detection may be served as the effective markers for the diagnosis of glioma.