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投稿时间：2021-10-24 网络发布日期：2022-06-20
投稿时间：2021-10-24 网络发布日期：2022-06-20
中文摘要: 高脂血症性急性胰腺炎（HLAP）通常是由于血清三酰甘油水平升高所致，HLAP与其他病因所致的急性胰腺炎（AP）相比，具有进展快、重症化、并发症多、易复发等特点，其与血清三酰甘油分解产生的游离脂肪酸及炎症因子通过直接或间接对胰腺及全身多器官的损伤作用密切相关，血液净化（BP）治疗可快速有效的降低血清三酰甘油及炎症介质水平，阻断炎症因子的瀑布级联反应，改善病情，且该方法在调节水电解质及酸碱平衡紊乱方面也有一定作用。目前将血液净化用于HLAP的治疗已得到大多数学者的认可，该文将近年来国内外BP在HLAP治疗方面的研究进展作一综述。
Abstract:Hyperlipidemic acute pancreatitis (HLAP) is usually caused by elevated serum triglyceride levels. Compared with acute pancreatitis (AP) caused by other causes, HLAP has the characteristics of rapid progress, severe, many complications and easy recurrence. It is closely related to the direct or indirect damage of free fatty acids and inflammatory factors produced by the decomposition of serum triacylglycerol to the pancreas and multiple organs of the whole body. Blood purification (BP) treatment can quickly and effectively reduce the levels of serum triacylglycerol and inflammatory mediators, block the cascade reaction of inflammatory factors, and improve the condition. This method also plays a certain role in regulating water electrolyte and acid-base balance disorder. At present, the use of blood purification in the treatment of HLAP has been recognized by most scholars. This paper reviews the research progress of BP in the treatment of HLAP at home and abroad in recent years.
keywords: Hyperlipidemia Acute pancreatitis Blood purification Hemoperfusion Plasma exchange Triacylglycerol
文章编号： 中图分类号：R576 文献标志码：A
基金项目:贵州省卫生健康委科学技术基金项目(gzwkj2021-127); 贵阳市科技局大健康科技合作计划项目(［2018］1-72)
| 作者 | 单位 |
| 张娟1，2 | 1. 贵州医科大学，贵州 贵阳 550000；2. 贵州医科大学附属白云医院消化科，贵州 贵阳 550014 |
| 雷静静3 | 3. 贵州医科大学附属医院综合病房（老年医学科），贵州 贵阳 550004 |
| 刘琦4 | 4. 贵州医科大学附属医院消化内科，贵州 贵阳 550004 |
| 王玉洁2 | 贵州医科大学附属白云医院消化科，贵州 贵阳 550014 |
| Author Name | Affiliation |
| ZHANG Juan*, LEI Jing-jing, LIU Qi， WANG Yu-jie | *Guizhou Medical University, Guiyang, Guizhou 550014, China |
引用文本：
张娟,雷静静,刘琦,等.高脂血症性急性胰腺炎血液净化的应用进展[J].中国临床研究,2022,35(6):844-848.
张娟,雷静静,刘琦,等.高脂血症性急性胰腺炎血液净化的应用进展[J].中国临床研究,2022,35(6):844-848.