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投稿时间：2021-04-21 网络发布日期：2021-12-20
投稿时间：2021-04-21 网络发布日期：2021-12-20
中文摘要: 目的 观察对椎-基底动脉供血不足性眩晕症（VBIV）采用长春西汀联合阿加曲班治疗的疗效及对患者炎症因子水平的影响。方法 选取河北北方学院附属第一医院2018年3月至2019年1月神经内科住院的VBIV患者100例，随机分为治疗组和对照组，每组50例。两组患者均予以基础治疗，在此基础上给予对照组长春西汀、治疗组长春西汀联合阿加曲班治疗，10 d为1个疗程。于治疗1个疗程后评价治疗效果，使用经颅多普勒超声（TCD）检查双侧椎动脉及基底动脉的血流速度变化，使用ELISA测定治疗前后炎症因子［C反应蛋白(CRP)、白细胞介素-6(IL-6)］水平；采用放射免疫法测定血管内皮细胞功能［内皮素（ET-1）、降钙素基因相关肽（CGRP）］的变化。结果 治疗1疗程后，治疗组总有效率高于对照组（96.0% vs 76.0%，P<0.05）；治疗组双侧椎动脉及基底动脉的血流速度均高于对照组（P<0.05）；治疗组IL-6、CRP、 ET-1水平低于对照组（P<0.05），CGRP水平高于对照组（P<0.05）。结论 长春西汀联合阿加曲班可提高VBIV患者椎基底动脉血流速度，降低患者血清炎性因子水平，减轻血管内皮损伤。
中文关键词: 长春西汀 阿加曲班 椎-基底动脉供血不足性眩晕症 炎性因子 血管内皮细胞
Abstract:Objective To observe the effect of vinpocetine combined with argatroban on vertebrobasilar insufficiency vertigo (VBIV) and its influences on inflammatory factors. Methods A total of 100 VBIV inpatients admitted to the First Affiliated Hospital of Hebei North University from March 2018 to January 2019 were randomly divided into treatment group and control group (n=50, each). Based on the routine treatment in both groups, vinpocetine was given in control group, and vinpocetine combined with argatroban was used in treatment group. After a 10-day treatment course, transcranial doppler (TCD) was used to determine the changes of blood flow velocity of bilateral vertebral artery and basilar artery, ELISA was used to detect the levels of C-reactive protein (CRP) and interleukin-6 (IL-6) before and after treatment, and radioimmunoassay was used to measure the changes of endothelin-1 (ET-1), calcitonin gene-related peptide (CGRP). Results The total effective rate in treatment group was significantly higher than that in control group (96.0% vs 76.0%, P<0.05). The blood flow velocity of the bilateral vertebral artery and basilar artery was higher in treatment group than that in control group (P<0.05). Compared with control group, the levels of IL-6, CRP and ET-1 decreased, and CGRP level increased in treatment group (P<0.05). Conclusion Vinpocetine combined with argatroban can improve the blood flow velocity of vertebrobasilar artery, and reduce the levels of serum inflammatory factors and vascular endothelial cells injury in VBIV patients.
keywords: Vinpocetine Argatroban Vertebrobasilar insufficiency vertigo Inflammatory factor Vascular endothelial cell
文章编号： 中图分类号：R741.05 文献标志码：B
基金项目:河北省卫生健康委员会基金项目（20180840）；张家口市级科技计划项目（1921063D，2121146D）
引用文本：
王刚，王欢欢，张晓敏，程怡，龚珊珊.长春西汀联合阿加曲班治疗椎-基底动脉供血不足性眩晕症的疗效[J].中国临床研究,2021,34(12):1655-1657.
王刚，王欢欢，张晓敏，程怡，龚珊珊.长春西汀联合阿加曲班治疗椎-基底动脉供血不足性眩晕症的疗效[J].中国临床研究,2021,34(12):1655-1657.