Abstract:Objective To explore the risk factors of bipolar disorder (BD) complicated with metabolic syndrome and provide references for the clinical prevention and treatment. Methods A retrospective analysis was conducted on 82 BD patients treated at Suzhou Second People's Hospital from December 2019 to March 2021. According to whether the patients were complicated with metabolic syndrome, they were divided into syndrome group and no-syndrome group (n=41, each). The data of patients’ age, gender, smoking history, course of disease, hypertension, diabetes and the types of antipsychotic drugs were collected, and blood pressure, blood glucose and lipids levels were detected. Logistic regression was used to analyze the risk factors of BD complicated with metabolic syndrome. Results There was no significant difference in the course of disease, age, gender, smoking history, diagnostic classification of antipsychotic and mood stabilizers between two groups (P>0.05). The incidence of family history of diabetes and the types of medication in no syndrome group were significantly lower than those in syndrome group (P<0.01). Multivariate Logistic regression analysis showed that family history of diabetes (OR=6.938,95% CI:1.227-39.238, P=0.028) and more types of medications (OR=3.016, 95%CI:1.256-7.244, P=0.014) were the risk factors of bipolar disorder complicated with metabolic syndrome. Conclusion The use of more types of antipsychotics and the history of diabetes are risk factors for bipolar disorder complicated with metabolic syndrome.