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投稿时间：2019-11-20 网络发布日期：2020-09-20
投稿时间：2019-11-20 网络发布日期：2020-09-20
中文摘要: 目的 分析CD64指数、降钙素原对耐多药肺结核(MDR-PTB)病情转归的预测作用。方法 回顾性分析2016年1月至2017年7月于接受标准化治疗的80例MDR-PTB患者的临床资料,依据其转归分为临床治愈组50例及失败组30例,对两组CD64指数、降钙素原进行测定及比较,并利用Pearson相关性分析法对CD64指数、降钙素原与MDR-PTB病情转归的相关性进行分析。结果 临床治愈组CD64指数、降钙素原均低于失败组［2.05±0.33 vs 6.78±0.30,(0.06±0.01)μg/L vs (0.64±0.10)μg/L,P<0.01］;失败组内初治患者CD64指数4.24±0.22、降钙素原(0.31±0.10)μg/L,复治患者CD64指数9.32±0.20、降钙素原(0.97±0.12)μg/L,二者相比较,初治患者均低于复治患者(P<0.01);Pearson相关性分析结果提示,CD64指数、降钙素原与MDR-PTB病情转归呈负相关性(r=-0.89、-0.85,P<0.05)。结论 CD64指数、降钙素原与MDR-PTB病情转归呈负相关性,数值越高,MDR-PTB患者转归越差,通过对以上指标数值进行测定有助于对其预后作出科学预测。
Abstract:Objective To analyze the predictive effect of CD64 index (an integral membrane glycoprotein) and procalcitonin(PCT) on the outcome of multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods The clinical data of 80 MDR-PTB patients who received standardized treatment from January 2016 to July 2017 were retrospectively analyzed.According to the outcome of patients, they were divided into clinical cure group (n=50) and failure group (n=30).CD64 index and PCT were measured and compared between two groups, and the associations of CD64 index and PCT with the prognosis of MDR-PTB were explored by Pearson correlation analysis. Results CD64 index(2.05±0.33 vs 6.78±0.30) and PCT ［(0.06±0.01)μg/L vs (0.64±0.10)μg/L］ in cure group were statistically lower than those in [JP2]failure group(all P<0.01).In failure group, CD64 index(4.24±0.22 vs 9.32±0.20) and PCT［(0.31±0.10)μg/L vs [JP](0.97±0.12)μg/L］ in the newly treated patients were significantly lower than those in the retreated patients(all P<0.01).Pearson correlation analysis showed that CD64 index and PCT were negatively correlated with MDR-PTB outcome (r=-0.89, -0.85, P<0.01). Conclusion Indexes of CD64 and PCT are negatively correlated with the outcome of patients with MDR-PTB and are helpful to determine the prognosis of patients.
文章编号： 中图分类号： 文献标志码：B
基金项目:
| Author Name | Affiliation |
| ZHANG Yu-xiang, Asmuguli Nurmaiti | Department of Laboratory, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830002, China |
引用文本：
张裕祥,阿斯木姑丽·努尔麦麦提.CD64指数与降钙素原对耐多药肺结核病情转归的预测作用[J].中国临床研究,2020,33(9):1224-1227.
张裕祥,阿斯木姑丽·努尔麦麦提.CD64指数与降钙素原对耐多药肺结核病情转归的预测作用[J].中国临床研究,2020,33(9):1224-1227.