Abstract:Objective To observe the changes of coagulation and fibrinolysis in different stages of chronic kidney disease(CKD) by thromboelastography(TEG) and routine coagulation test,so as to provide reference for the diagnosis,treatment and prognosis of CKD. Methods The function of coagulation and fibrinolysis of 170 patients with CKD(CKD group) and 100 healthy people (control group) admitted from June 2017 to December 2018 were analyzed by TEG and conventional coagulation test.The CKD group was divided into 5 subgroups (28 cases in CKD1-2 stage group,36 cases in CKD3 stage group,31 cases in CKD4 stage group,43 cases in CKD5 stage non dialysis group and 32 cases in CKD5 stage dialysis group) according to the stage standard of K/DOQI guideline,the research results were obtained through data sorting and operation. Results There were significant differences in TEG parameters (R,K,α,MA) and routine coagulation items (PT,APTT,INR,FIB,TT) between the control group and the CKD group (P<0.05,P<0.01).In the test results of TEG,there was no difference in the changes of fibrinolytic function parameters (EPL,ly30) among the subgroups of the CKD group (P>0.05).In the results of routine coagulation test,there was a significant difference between the parameters of fibrinolysis in CKD1-2 group and other subgroups in the CKD group (P<0.0125),but no significant difference between the other subgroups (P>0.0125).The two methods indicated that the cumulative number of patients with hyperfibrinolysis accounted for 40.00% of the CKD group,and together showed that patients with hyperfibrinolysis accounted for 14.71% of the total cases of hyperfibrinolysis.The difference between the two methods in the detection of fibrinolysis was large,and there was no consistency (Kappa=0.054,P>0.05). Conclusions The TEG and conventional coagulation test are complementary to each other in the determination of coagulation and fibrinolysis function.They can reflect the real state of the body from different angles,and provide the basis for clinical diagnosis and treatment in a timely and efficient manner.