Abstract:Objective To investigate the clinical efficacy of operation without deep hypothermic circulatory arrest for DeBakey Ⅰ aortic dissection. Methods Fifty patients with DeBakey Ⅰ aortic dissection admitted in Handan Central Hospital from January 2014 to January 2017 were selected as research objects. The patients were divided into two groups according to different circulatory arrest methods: study group (n=20, without deep hypothermic circulatory arrest) and control group (n=30, with deep hypothermic circulatory arrest). The operation was performed under cardiopulmonary bypass (CPB) in both two groups. CPB time, ascending aorta crossclamp time, cerebral perfusion time, oxygenation index at different time points, amount of postoperative drainage, length of ICU stay, length of hospital stay were recoded, and postoperative adverse conditions were counted. Results CPB time [(179.9±61.2) min], ascending aorta crossclamp time [(86.2±27.9) min] and cerebral perfusion time [(51.9±11.5) min] in study group were all lower than those in control group [(205.5±64.5) min, (93.1±25.2) min and (53.6±13.2) min], while there were no significant differences in them between two groups (all P>0.05). At the end of CPB, 2 hours after end of CPB and 4 hours after end of CPB, the oxygenation indexes showed a downward trend in two groups, but they at same time points in control group were all significantly lower than those in study group (all P<0.05). The oxygenation indexes increased significantly 8 hours after end of CPB in both two groups, and it in study group was significantly higher than that in control group (P<0.05). The amount of postoperative drainage [(780.72±151.56) ml], ventilator use time [(11.95±3.72) h], length of ICU stay [(2.21±1.47) d] and length of hospital stay [(13.25±3.41) d] in study group were all significantly lower than those [(1 006.12±341.87) ml, (14.76±4.13) h, (3.19±1.23) d and (15.68±3.72) d] in control group (all P<0.05). The re-thoracotomy operation, disturbance of consciousness, coma and death were found in 1 case, 1 case, 0 case, 0 case, respectively in study group and in 4 cases, 5 cases, 2 cases, 3 cases, respectively in control group, while there were no significant differences in them between two groups (P>0.05). Conclusion Application of circulatory arrest without deep hypothermia can effectively reduce amount of postoperative drainage, ventilator use time, length of ICU stay and length of hospital stay, improve oxygenation index after end of CPB and is in favor of the decrease of postoperative complications compared with the method without deep hypothermic circulatory arrest in the operation of DeBakey type Ⅰ aortic dissection.