Abstract:Objective To investigate the current situation of hope level, social support and coping style of patients with primary liver cancer（PLC）, and to explore the mediating effect of social support, so as to provide reference for improving the hope level of patients. Methods The convenience sampling method was used for the questionnaire survey. The patients in the hepatobiliary surgery ward of the First Affiliated Hospital of China Medical University from October 2020 to June 2021 were continuously selected. The Herth Hope Scale, Social Support Rating Scale, Medical Coping Modes Questionnaire and Self-designed General Information Questionnaire were used for the questionnaire survey and collection. A total of 220 cases were investigated in this study, and invalid questionnaires were excluded after distribution. The final effective samples were 206, and the effective rate of questionnaire recovery was 93.64%. Results The hope level of PLC patients was at the medium and low level ［（30.74±5.83） points］. The total score and each dimension of hope level, the total score and each dimension of social support, and the dimension of face coping style were positively correlated with each other（P＜0.01）. The total score and each dimension of hope level and the total score and each dimension of social support were negatively correlated with the two dimensions of avoidance and submission respectively（P＜0.05, P＜0.01）. Coping style had an indirect preditive effect on the hope leve1 through the intermediary role of social support（β=-0.191）, the amount of mediating effect was 48.1%, and the mediating effect was significant. Conclusion The hope level of PLC patients is at medium and low level. Coping style can not only directly predict the hope level of PLC patients, but also indirectly control the hope level of patients through social support as an intermediary variable.