Abstract:Objective To investigate the perioperative anesthesia management of rare vasoactive intestinal peptidoma（VIPoma）. Methods The perioperative anesthesia management experience of a patient who was admitted to Xiangan Hospital on November 11 to 24, 2019, complained of continuous diarrhea for 6 years, diagnosed neuroendocrine tumors, and underwent elective laparotomy with retroperitoneal tumor resection and radiofrequency ablation was retrospectively summarized. Results General anesthesia combined with pharyngeal surface anesthesia 〖JP2〗and bilateral transverse abdominal muscle plane block were performed during the operation. Comprehensive anesthesia management includes: preoperative octreotide treatment; improve preoperative preparations such as potassium supplement, acid correction and inhibition of vasoactive intestinal peptide（VIP）; intraoperative monitoring of invasive blood pressure and dynamic monitoring of blood gas analysis; focus on maintaining hemodynamic stability, water and electrolyte balance and protecting important organ functions. The operation was successfully completed, the patients diarrhea symptoms disappeared, the electrolyte level returned to normal and stable, improved and discharged from the hospital. Conclusion The perioperative anesthesia management of VIPoma is complex and risky, but grasping the preoperative basis of the tumor patient and the characteristics of hemodynamic fluctuation during operation, preparing a good anesthesia plan, selecting appropriate anesthesia methods and careful comprehensive management are conducive to ensure the success of the operation.