Abstract:Objective To investigate the diagnostic value of thrombin-antithrombin complex(TAT), plasmin-α2-plasmin inhibitor complex(PIC), soluble thrombomodulin(sTM) and tissue plasminogen activator inhibitor complex (t-PAIC) in patients with chronic obstructive pulmonary disease （COPD） complicated with deep vein thrombosis(DVT). Methods Retrospective analysis was performed on 173 COPD patients admitted to the ICU of Panzhihua Central Hospital from February 2020 to February 2021. The patients were divided into thrombotic group (53 cases) and non-thrombotic group (120 cases) according to whether they had DVT, and 50 healthy subjects were selected as control group. The level of TAT, PIC, sTM and t-PAIC were analyzed and ROC curve was further analyzed. Results The levels of TAT, PIC, sTM and t-PAIC in the thrombus group were higher than those in the non-thrombus group and the control group, the levels of PIC, sTM and t-PAIC in the non-thrombus group were higher than those in the control group, the difference was statistically significant (P<0.01). The ROC curve showed that for single thrombus marker detection, TAT had the highest diagnostic AUC (0.794) and specificity (80.6%), PIC had the highest sensitivity (81.9%). The sensitivity (82.4%) and specificity (81.5%) and AUC (0.904) of TAT combined with PIC were higher than those of single diagnosis. Conclusion TAT, PIC, sTM, t-PAIC have certain diagnostic value for COPD patients with DVT, and the combination of TAT and PIC have higher diagnostic value.