Abstract:Objective To explore the clinical therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) combined with selegiline on the Parkinsons disease(PD) patient with frozen gait. Methods Fifty-six PD patients with frozen gait were continuously recruited from June 2019 to December 2020 and randomly divided into rTMS group and control group ( n =28, each). Low-frequency rTMS with oral selegiline tablets was given in rTMS group, and pseudo-coil rTMS with oral selegiline tablets was used in control group. In both groups, the patients were treated with oral selegiline 5 mg twice a day and rTMS once a day (20 min each time) for 14 consecutive days. Unified Parkinsons rating scale (UPDRS), freezing of gait questionnaire(FOGQ), Berg balance scale (BBS), Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to assess the situation of patients in two groups. Results Compared with those before treatment and in control group, the scores of UPDRS-Ⅱ，UPDRS-Ⅲ and FOGQ decreased significantly,and BBS score increased in rTMS group after treatment( P <0.01）.UPDRS-Ⅰ, UPDRS-Ⅳ, HAMA and HAMD in rTMS group were statistically lower than those before treatment and in control group（ P <0.05）. Conclusion The rTMS combined with selegiline can effectively improve gait disorders in Parkinsons disease patients with frozen gait, as well as the non motor symptoms such as anxiety, depression and PD drug complications.