Abstract:This paper reviewed two patients with refractory mycoplasma pneumoniae pneumonia with cardiac thrombosis. Two patients were fever and cough. During the course of the course, echocardiography was performed to find the heart thrombosis, but the patients did not show the clinical manifestations related to embolism. Mycoplasma pneumoniae pneumonia combined with cardiac thrombosis is rare in clinical, generally without specific clinical manifestations. Clinicians should be vigilant. When there are risk factors of thrombosis, relevant examination should be conducted to avoid missed diagnosis.