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投稿时间：2020-04-07 网络发布日期：2021-01-20
投稿时间：2020-04-07 网络发布日期：2021-01-20
中文摘要: 目的 采用Meta分析的方法,探讨肾脏总体积（TKV）对常染色体显性遗传性多囊肾病（ADPKD）病情进展及预后判断的价值。
方法 运用计算机检索Cochrane Library、PubMed、Embase、中国知网(CNKI)等数据库,检索ADPKD患者TKV和病情进展及预后判断相关的文献,检索期限为各数据库建库至2019年9月。由两名研究人员按纳入及排除标准独立进行文献筛选、质量评价、文献基本特征及相关数据提取等工作,运用Stata 12.0软件进行Meta分析评价。
结果 最终纳入研究13项,纳入样本量共1 982例。Meta分析结果显示,TKV对ADPKD病情变化有中等强度的预测价值(r=-0.45,95%CI:-0.49~-0.41);按照地区进行亚组分析显示,北美地区为(r=-0.46,95%CI:-0.50~-0.42),在亚洲为(r=-0.38,95%CI:-0.48~-0.27),在欧洲则为(r=-0.46,95%CI:-0.60~-0.29);按照肾脏测量方法进行亚组分析:Ultrasound组(r=-0.50,95%CI:-0.56~-0.42);MRI组(r=-0.44,95%CI:-0.48~-0.40)。
结论 TKV对于ADPKD的预后和病情进展有着中等强度的预测价值。这种预测价值在不同地区及不同测量方式会有一定差异,但不影响整体结果,故可作为临床及药物试验中监测ADPKD患者病情的有效指标。
中文关键词: 常染色体显性遗传性多囊肾病 肾脏总体积 肾小球滤过率 预后判断 荟萃分析
Abstract:Objective To explore the value of total kidney volume (TKV) in predicting the progression and prognosis of autosomal dominant polycystic kidney disease (ADPKD).
Methods Cochrane Library,PubMed,Embase,CNKI and other databases were searched for the literatures on the associations of TKV with disease progression and prognosis in the patients with ADPKD.The retrieval period was from the establishment of each database to September 2019.After meeting the inclusion and exclusion criteria,literature screening,quality assessment,basic characteristics of literature and related data extraction were carried out,and Meta-analysis was performed by STATA 12.0 software.
Results There were 1 982 ADPKD patients involved in 13 literature studies.Meta-analysis showed that TKV had a moderate predictive value for the severity of ADPKD（r=-0.45,95%CI：-0.49--0.41）.Subgroup analysis by region showed the predictive value of TKV in North America (r=-0.46,95%CI:-0.50--0.42),in Asia (r=-0.38,95%CI:-0.48--0.27) and in Europe (r=-0.46,95%CI:-0.60--0.29).Subgroup analysis by kidney measurement method showed that TKV had predictive value in ultrasound group(r=-0.50,95%CI:-0.56--0.42) and in MRI group(r=-0.44,95%CI:-0.48--0.40).
Conclusions TKV has a moderate predictive value for the prognosis and disease progression of ADPKD and may vary in different regions and different measurement method,but does not affect the overall results.It can be used as an effective indicator for monitoring the condition of patients with ADPKD in clinical and drug trials.
keywords: Autosomal dominant polycystic kidney disease Total kidney volume Estimated glomerular filtration rate Prognosis judgment Meta-analysis
文章编号： 中图分类号：R692.1 文献标志码：A
基金项目:
| Author Name | Affiliation |
| HU Jiang-tao*,ZHOU Yun | *Department of Nephrology,Shanxi Medical University,Taiyuan,Shanxi 030000,China |
引用文本：
胡江涛 ,周芸.肾脏总体积对常染色体显性多囊肾病病情进展和预后评估价值的Meta分析[J].中国临床研究,2021,34(1):32-36,42.
胡江涛 ,周芸.肾脏总体积对常染色体显性多囊肾病病情进展和预后评估价值的Meta分析[J].中国临床研究,2021,34(1):32-36,42.