Abstract:Objective To investigate the feasibility of transurethral resection of bladder tumor(TURBT) for muscle-invasive bladder urothelial carcinoma (MIBUC) and its impact on quality of patients' life. Methods A total of 64 MIBUC patients operated from June 2010 to June 2013 were randomly divided into TURBT group and partial cystectomy (PC) group (n=32, each). The quality of life and 1-, 3-, 5-year survival rates were compared between two groups. Results The operative time, intra-operative blood loss, postoperative bladder irrigation time, hospital stay and complication rate in TURBT group were significantly lower than those in PC group (all P<0.01). At 6 months after operation, the functional scores and overall health score of Quality of Life Questionnaire Core 30(QLQ-C30) of TURBT group were significantly higher than those of preoperative and PC group, and symptom scores were significantly lower than those of preoperative and PC group (P<0.05, P<0.01). The disease-free survival (DFS) and overall survival (OS) times were 34.56 and 45.11 months in TURBT group and 35.31 and 47.39 months in PC group, and there were no significant differences between two groups (all P>0.05). Also, there were no significant differences in recurrence rate (30.00% vs 27.59%), 1-, 3-, 5-year DFS rates and OS rates between TURBT group and PC group (all P>0.05). Conclusion Selective TURBT is safe and feasible for the treatment of MIBUC, which can reduce surgical trauma, accelerate the recovery and improve the quality of life.