Abstract:Objective To investigate the Effect of self-made Dahuang Shuizhi decoction on blood lipid level in patients with diabetes mellitus. Methods A total of 80 diabetes patients combined with hyperlipidemia who received treatment at No.4 People′s Hospital of Hengshui from August 2016 to August 2018 were selected and divided into control group and observation group randomly (n=40, each).The control group was treated with simvastatin, and the observation group was treated with self-madeDahuang Shuizhi decoction.The clinical efficacy, and adverse reactions of the two groups were compared.The blood lipid levels before, 2 weeks and 4 weeks after the treatment were detected and compared. Results The clinical total effective rate of the observation group was significantly higher than that of the control group (95.0% vs 80.0%, χ²=4.114, P=0.043).After 2 and 4 weeks of treatment, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in the observation group were significantly lower than those in the control group, while the high-density lipoprotein cholesterol (HDL-C) in the observation group was higher than that in the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group (2.5% vs 10.0%, χ²=1.920, P=0.166). Conclusion The effect of self-madeDahuang Shuizhi decoction on reducing blood lipid is better than simvastatin, especially in the treatment of hyperlipidemia in diabetic patients.