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投稿时间：2020-03-15 网络发布日期：2020-08-20
投稿时间：2020-03-15 网络发布日期：2020-08-20
中文摘要: 目的 观察益气健脾方治疗恶性肿瘤患者化疗后疲乏的临床疗效及对免疫功能的影响。方法 将2018年1月至2020年5月36例恶性肿瘤化疗患者按入院时间随机分为益气健脾方给药组(18例)和对照组(18例)。两组患者根据病情需要进行化疗，给药组在化疗结束后第3天开始口服益气健脾方,每日1剂,连用10 d；对照组不给予特殊治疗。采用简短疲乏量表、中医症状评分、生活质量量表（SF-36）比较两组患者化疗后疲乏情况,并检测两组患者治疗前后血清炎性因子白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α和IL-1β水平及外周血CD3+、CD4+、CD8+ 及CD4+/CD8+T淋巴细胞比例。结果 化疗后1、2周,给药组癌性疲乏评分显著低于对照组,差异有统计学意义(P<0.01)。给药组总有效率显著高于对照组,差异有统计学意义(94.44% vs 44.45%,P<0.01)。给药组总体健康、情感职能、精神健康、精力、社会功能、生理机能评分均高于对照组(P<0.05,P<0.01)。两组治疗后IL-6、TNF-α和IL-1β水平均低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组CD3+、CD4+、CD8+和CD4+/CD8+均高于治疗前,且观察组高于对照组(P<0.05)。结论 益气健脾方能明显缓解恶性肿瘤患者化疗后疲乏状态,提高患者生活质量,也可降低促炎细胞因子水平,恢复T淋巴细胞功能等免疫调节。
Abstract:ObjectiveTo investigate the clinical efficacy and immunological evaluation of Yiqi Jianpi Decoction in the treatment of fatigue after chemotherapy in patients with malignant tumor.MethodsA total of 36 patients with malignant tumor who received chemotherapy from January 2018 to May 2020 were randomly divided into Yiqi Jianpi Decoction group (treatment group,18 cases) and control group (18 cases).All the patients received chemotherapy according to the needs.The treatment group was given Yiqi Jianpi Decoction orally on the third day after chemotherapy,1 dose a day for 10 days.The control group was not given any traditional Chinese Medicine.The short fatigue score,TCM symptom score and quality of life score(SF-36) were used to compare the fatigue of the two groups after chemotherapy,and the inflammatory factors levels of serum IL-6,TNF-α and IL-1 β,the percentage of peripheral blood CD3+,CD4+,CD8+ and the ratio of CD4+/CD8+T lymphocytes were measured before and after treatment.ResultsAt 1 and 2 weeks after chemotherapy,the cancer fatigue score of the treatment group was significantly lower than that of the control group (P<0.01).The total effective rate of the treatment group was significantly higher than that of the control group (94.44% vs 44.45%,P<0.01).The scores of general health,emotional function,mental health,energy,social function and physiological function in the treatment group were higher than those in the control group (P<0.05,P<0.01).The levels of IL-6,TNF-α and IL-1 β in the two groups after treatment were lower than those before treatment,and those in the treatment group were lower than those in the control group (P<0.05).After treatment,CD3+,CD4+,CD8+ and CD4+/CD8+ in the two groups were higher than those before treatment,and those in treatment group were higher than those control group (P<0.05).ConclusionYiqi Jianpi Decoction can significantly relieve the fatigue state of patients with malignant tumor after chemotherapy,improve the quality of life of patients,reduce the level of pro-inflammatory cytokines,restore the function of T lymphocytes and other immune regulation.
keywords: Cancer fatigue Yiqi Jianpi Decoction Malignant tumor Traditional Chinese medicine Immune function
文章编号： 中图分类号： 文献标志码：B
基金项目:
| Author Name | Affiliation |
| CAO Yong-yi,ZHU Ting | Department of Oncology,Hefei First People′s Hospital,Hefei,Anhui 230031,China |
引用文本：
曹永一,朱婷.益气健脾方对恶性肿瘤患者化疗后疲乏的作用[J].中国临床研究,2020,33(8):1115-1118.
曹永一,朱婷.益气健脾方对恶性肿瘤患者化疗后疲乏的作用[J].中国临床研究,2020,33(8):1115-1118.