Abstract:ObjectiveTo investigate the effect of low molecular weight heparin(LMWH) in the treatment of fetal intrauterine growth restriction (FGR) and its influence on the structure of placenta electron microscope and the expression of formate peptide receptor 2 (FPR2).MethodsThe clinical data of 98 patients with FGR who were treated in obstetrics and gynecology from November 2017 to January 2019 were analyzed retrospectively.The patients were divided into research group (n=50),routine group (n=32) and control group (n=16) according to the treatment method.The research group was given LMWH treatment,the conventional group was given conventional treatment,and the control group was given no special treatment.The clinical treatment effects of the three groups were compared,and the immunohistochemical SP method was used to detect the expression levels of FPR2 in the placental tissue of each group,and the ultrastructure of the placenta was observed by transmission electron microscopy.ResultsThe total effective rate of clinical treatment of FGR in research group(90.00%) was higher than that in control group(56.25%)(P<0.017).Transmission electron microscopy showed that the surface of syncytiotrophoblasts in the placenta of research group contained a large number of neat microvilli,which were finger-like.The cytoplasm was rich in rough endoplasmic reticulum and mitochondria.The nuclear chromatin was dense and evenly distributed.There were fewer collagen fibers and dilated capillaries.The expression level and staining intensity of FPR2 protein in trophoblast cells,villous interstitial cells and endothelial cells of FGR placenta were as follows:research group>conventional group>control group(P<0.01).ConclusionThe clinical effect of LMWH on FGR is obvious,and at the same time,it can effectively improve the ultrastructure of placental tissue and increase the expression level of FPR2 protein in placenta.