Abstract:ObjectiveTo evaluate the application of intravascular ultrasound (IVUS) and fractional flow reserve(FFR) on percutaneous coronary intervention (PCI) and the clinical effects in patients with multivessel coronary artery disease.MethodsFifty-four patients with multivessel coronary artery disease from January 2012 to April 2014 were randomly divided into FFR group (n=17),IVUS group (n=19) and coronary arteriography(CAG) group (n=18).In FFR group,intracoronary stent implantation was performed for coronary stenosis by FFR ≤0.80 in 41 lesions.In IVUS group,stents were placed in 43 coronary lesions with minimal lumen cross-sectional area (CSA) <4 mm2.In CAG group,routine stent implantation was performed in 40 lesions with more than 70% stenosis according to the results of CAG.The number of stents implanted,the incidences of chest pain and major cardiovascular events (MACE) one year later were compared among the three groups.ResultsThe number of stent implanted in FFR group（1.71±0.47）was significantly less than that in CAG group（2.33±0.49,P＜0.01）and in IVUS group（2.00±0.33,P=0.05),respectively,and the number of stent was statistically less in IVUS group than that in CAG group(P<0.05).There were no significant differences in the incidences of MACE and angina pectoris during one-year follow-up period among three groups (P＞0.05).ConclusionBoth IVUS and FFR can be used to guide PCI in patients with multi vessel coronary disease,however,FFR- guided PCI can reduce the number of stent and the rate of coronary revascularization.