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投稿时间：2019-08-27 网络发布日期：2020-04-20
投稿时间：2019-08-27 网络发布日期：2020-04-20
中文摘要: 目的 分析章丘地区反复呼吸道感染(RRTI)儿童维生素A(VitA)、VitE水平与白细胞计数(WBC)、C反应蛋白(CRP)、血红蛋白(Hb)联合测定的临床意义。
方法 选取2017年2月至2019年2月济南市章丘区人民医院儿科收治的5 000例RRTI患儿为RRTI组,根据年龄分为1～2岁(n=2 015)、3～5岁(n=1 839)、6～14岁(n=1 146),依据疾病分为上呼吸道感染(n=1 558)、支气管炎(n=1 241)、支气管肺炎(n=1 119)、支气管哮喘(n=1 082),并选取同期非RRTI儿童5 000例作为对照组,根据年龄分为1～2岁(n=2 023)、3～5岁(n=1 845)、6～14岁(n=1 132),比较各特征儿童血清VitA、VitE、WBC、CRP、Hb水平,采用Spearman分析不同年龄、疾病儿童VitA、VitE水平与WBC、CRP、Hb间的相关性。
结果 1～2、3～5、6～14岁RRTI患儿VitA、VitE、Hb均低于对照组,WBC、CRP均高于对照组(P均<0.01);1～2、3～5、6～14岁RRTI患儿VitA均与WBC、CRP呈负相关,均与Hb呈正相关(P<0.05，P<0.01);不同年龄VitE水平与WBC、CRP、Hb均无相关性(P均>0.05);上呼吸道感染、支气管炎、支气管肺炎、支气管哮喘患儿VitA、VitE、Hb低于对照组,WBC、CRP高于对照组(P均<0.05);支气管哮喘患儿VitA、VitE、Hb水平最低,支气管肺炎患儿WBC、CRP最高(P均<0.05);上呼吸道感染、支气管炎、支气管肺炎、支气管哮喘患儿VitA均与WBC、CRP呈负相关(P均<0.05);支气管肺炎、支气管哮喘患儿VitE亦与WBC、CRP呈负相关(P均<0.05);支气管哮喘患儿VitA、VitE与Hb呈正相关(P均<0.05)。
结论 与非RRTI儿童相比,章丘地区RRTI儿童VitA、VitE水平较低,VitA缺乏为RRTI独立危险因素,并与患儿贫血相关,VitE缺乏与支气管肺炎、哮喘有关。
Abstract:Objective To analyze the clinical significance of combined determination of vitamin A (VitA),VitE and white blood cell count (WBC),C-reactive protein (CRP) and hemoglobin (Hb) in children with recurrent respiratory tract infection (RRTI) in Zhangqiu area.
Methods From February 2017 to February 2019,5 000 children with RRTI were selected as RRTI group and divided into 1-2-year-old group(n=2 015),3-5-year-old group(n=1 839),6-14-year-old group(n=1 146).According to the disease type,they were divided into upper respiratory tract infection group(n=1 558),bronchitis group (n=1 241),bronchial pneumonia group(n=1 119),bronchial asthma group(n=1 082).At the same period,5 000 children with non-RRTI were served as controls and divided into 1-2-year-old group(n=2 023),3-5-year-old group(n=1 845) and 6-14-year-old group(n=1 132).The serum levels of VitA,VitE,WBC,CRP and Hb were compared among different groups,and Spearman was used to analyze the correlation between levels of VitA,VitE and levels of WBC,CRP and Hb in different ages and different diseases.
Results The levels of VitA,E and Hb in RRTI children of all age groups were lower than those in control group,and the levels of WBC and CRP were higher than those in control group(all P<0.01).In RRTI children of different age groups,VitA was negatively correlated with WBC and CRP,and was positively correlated with Hb (P<0.05,P<0.01),however,VitE was not correlated with WBC,CRP and Hb (all P>0.05).Compared with control group,the levels of VitA,E and Hb decreased,and the levels of WBC and CRP increased significantly in RRTI group(children of upper respiratory tract infection,bronchitis,bronchial pneumonia,bronchial asthma)(all P<0.05).The levels of VitA,E,Hb in asthmatic cases were the lowest,and the levels of WBC and CRP in bronchopneumonia cases were the highest (all P<0.05).In RRTI group,VitA was negatively correlated with WBC,CRP (all P<0.05);in bronchial pneumonia cases and bronchial asthma cases,VitE was negatively correlated with WBC and CRP;in bronchial asthma cases,VitA,and VitE were positively correlated with Hb (all P<0.05).
Conclusions Compared with non-RRTI children,the levels of VitA and VitE are lower in RRTI children of Zhangqiu area.VitA deficiency is an independent risk factor for RRTI and is associated with anemia in children.VitE deficiency is associated with bronchopneumonia and asthma.
keywords: Recurrent respiratory tract infection Children Vitamin A Vitamin E Leukocyte count C-reactive protein Hemoglobin
文章编号： 中图分类号： 文献标志码：B
基金项目:国家卫生计生委医药卫生科技发展研究中心项目(W2015EAE096)
| Author Name | Affiliation |
| KONG Li-mei,LI Chao,ZHANG Xiao-wei | Department of Pediatrics,Jinan Zhangqiu District People′s Hospital,Jinan,Shandong 250200,China |
引用文本：
孔丽梅,李超,张晓蔚.章丘地区反复呼吸道感染儿童维生素A、E水平与WBC、CRP、Hb联合测定的临床意义[J].中国临床研究,2020,33(4):512-516.
孔丽梅,李超,张晓蔚.章丘地区反复呼吸道感染儿童维生素A、E水平与WBC、CRP、Hb联合测定的临床意义[J].中国临床研究,2020,33(4):512-516.