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投稿时间：2019-05-26 网络发布日期：2020-02-20
投稿时间：2019-05-26 网络发布日期：2020-02-20
中文摘要: 目的 探讨妊娠相关蛋白A(PAPPA)联合人绒毛膜促性腺激素(HCG)在先兆流产患者中的水平及与妊娠不良结局的关系。方法 选取2017年1月至2018年8月收治的92例先兆流产患者为研究组,并将同期体检的92例正常孕妇作为对照组,比较两组HCG、PAPPA、孕酮水平,及不良妊娠结果,分析PAPPA联合HCG在先兆流产患者中与妊娠不良结局相关性。结果研究组HCG、PAPPA、孕酮水平均显著低于对照组(P<0.01)。研究组流产、死胎和早产等不良妊娠结局总发生率显著高于对照组,差异有统计学意义(23.91% vs 4.35%,P<0.01)。HCG、孕酮、PAPPA为先兆流产患者妊娠不良结局的独立影响因素。PAPPA联合HCG检测特异度、灵敏度、准确性明显高于单独PAPPA和单独HCG检测(P<0.05)。结论PAPPA联合HCG指标进行检测,可对先兆流产患者妊娠不良结局进行预测。
Abstract:Objective To investigate the levels of pregnancy associated plasma protein A(PAPPA) and human chorionic gonadotropin (HCG) in patients with threatened abortion and their correlation with adverse pregnancy outcomes.Methods A total of 92 patients with threatened abortion admitted from January 2017 to August 2018 were selected as group,and 92 normal pregnant women in the same period were served as control group.The levels of HCG,PAPPA,progesterone and the adverse pregnancy results were compared between two groups,and the associations of PAPPA and HCG with adverse pregnancy outcome and their diagnostic value were analyzed.Results The levels of HCG,PAPPA and progesterone in observation group were significantly lower than those in control group (P<0.01).In observation group,the total incidence of miscarriage,stillbirth and premature delivery significantly increased(23.91% vs 4.35%,P<0.01).HCG,progesterone and PAPPA were the independent influencing factors of adverse pregnancy outcome in patients with threatened abortion.The specificity,sensitivity and accuracy of joint detection of PAPPA and HCG were significantly higher than those of PAPPA or HCG detection alone (P<0.05).Conclusion The joint detection of PAPPA and HCG can determine the adverse outcome of pregnancy in patients with threatened abortion.
keywords: Threatened abortion Pregnancy associated plasma protein A Human chorionic gonadotropin Progesterone Pregnancy outcomes Correlation
文章编号： 中图分类号： 文献标志码：B
基金项目:广东省医学科研基金立项课题(201703632)
| Author Name | Affiliation |
| YAN Dongqin,TAN Qin,LIN Xiaolan | Department of Gynecology and Obstetrics,Affiliated Xiaolan Hospital,Sourthern Medical University,Zhongshan,Guangdong 528415,China |
引用文本：
严东琴,谭琴,林晓岚.PAPPA联合HCG在先兆流产患者中的检测水平及与妊娠不良结局的相关性[J].中国临床研究,2020,33(2):186-188，193.
严东琴,谭琴,林晓岚.PAPPA联合HCG在先兆流产患者中的检测水平及与妊娠不良结局的相关性[J].中国临床研究,2020,33(2):186-188，193.