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投稿时间：2019-05-15 网络发布日期：2020-01-20
投稿时间：2019-05-15 网络发布日期：2020-01-20
中文摘要: 目的 探讨即刻早期反应基因-1(IEX-1)在乳腺癌新辅助化疗(NCT)后表达的变化及在预后判断中的意义。
方法 选取2012年1月至2017年1月首诊首治并接受NCT的110例乳腺癌女性患者作为研究对象进行回顾性研究,采用二步法免疫组化方法检测NCT前后乳腺癌组织中IEX-1表达的变化,采用Kaplan-Meier和Log-rank法分析其对无病生存期(DFS)及总生存期(OS)的影响。
结果 NCT前乳腺癌组织中IEX-1蛋白均阴性;NCT后,IEX-1蛋白阳性表达45例(40.9%),阴性65例。生存分析显示,IEX-1蛋白阳性表达组患者的DFS、OS均低于IEX-1蛋白阴性表达组(P均<0.01)。多因素Cox比例风险回归模型分析发现,IEX-1蛋白阳性表达为乳腺癌预后的独立风险因素［HR=4.921,95%CI=(1.273～19.018),P=0.021］。
结论 乳腺癌NCT前后检测IEX-1有助于预后判断,IEX-1可能成为乳腺癌NCT疗效的预后指标。
中文关键词: 即刻早期反应基因-1 乳腺癌 新辅助化疗 预后
Abstract:Objective To investigate the expression changes of immediate early response gene X-1(IEX-1) and its prognostic significance in patients with breast cancer after neoadjuvant chemotherapy (NCT).
Methods A retrospective study was performed in 110 female patients with breast cancer treated with NCT from January 2012 to January 2017.The expressions of IEX-1 were detected by two-step immunohistochemical method before and after NCT,and its influences on DFS and OS were analyzed by Kaplan-Meier and Log-rank method.
Results The expression of IEX-1 protein was negative in all breast cancer tissues before NCT and was positive in 45 cases (40.9%) and negative in 65 cases after NCT.Survival analysis showed that DFS and OS of patients with positive IEX-1 protein were statistically lower than those with negative IEX-1 protein(all P<0.01).Multivariate Cox proportional hazard regression model analysis showed that positive expression of IEX-1 protein was an independent risk factor for prognosis of patients with breast cancer ［HR=4.921,95% CI(1.273-19.018),P=0.021］.
Conclusions The detection of IEX-1 before and after NCT is helpful to the assessment of prognosis of breast cancer.IEX-1 may be an indicator in evaluating the efficacy of NCT for breast cancer.
文章编号： 中图分类号： 文献标志码：A
基金项目:
| Author Name | Affiliation |
| WANG Bo* ,DONG Xiao-lin | * Department of Organ Transplantation and Breast Surgery,Affiliated Dong Feng Hospital of Hubei University of Medicine,Shiyan,Hubei 442000,China |
引用文本：
王波,董小林.即刻早期反应基因-1在乳腺癌新辅助化疗后表达的变化及对预后的意义[J].中国临床研究,2020,33(1):6-9.
王波,董小林.即刻早期反应基因-1在乳腺癌新辅助化疗后表达的变化及对预后的意义[J].中国临床研究,2020,33(1):6-9.