Abstract:Objective To assess growth differentiation factor-15(GDF-15) status in patients with type 2 diabetic nephropathy (DN) and its relation to inflammatory parameters,such as high sensitive C-reactive protein (hs-CRP),interleukin-17A (IL-17A). Methods A total of 144 DN patients treated from 2015 to 2016 were selected and divided into macroalbuminuria group (group A,n=26),microalbuminuria group (group B,n=60) and normal albuminuria group (group C,n=58) according to urinary protein content.The concentrations of cystatin C (Cys-C) and hs-CRP in serum were detected by immunoturbidimetry,and GDF-15 and IL-17A were detected by ELISA.The associations of GDF-15 with various indexes were analyzed. Results The course of diabetes,the levels of GDF-15,IL-17A,Cys-C and hs-CRP in group A were significantly higher than those in group B and group C (all P<0.05),and there were no significant differences in them between group B and group C (P>0.05).Partial correlation analysis showed that GDF-15 was positively correlated with urinary microalbumin (mAlb) (r=0.280,P<0.01),Cys-C (r=0.184,P<0.01),but not correlated with the course of diabetes (r=0.097,P>0.05),hs-CRP (r=0.147,P>0.05),IL-17A (r=-0.660,P>0.05). ConclusionGDF-15 is closely related to the occurrence and development of type 2 diabetic nephropathy.