Abstract:ObjectiveTo investigate the clinical effect of Kanli Jiaotai decoction combined with heart and kidney channel manipulation in the treatment of female menopausal syndrome. Methods From May 2015 to October 2017,72 female patients with climacteric syndrome were divided into observation group (36 cases,treated with Kanli Jiaotai decoction combined with massage of heart and kidney meridians) and control group (36 cases treated with Nilestriol) according to the design principles of prospective,matched (same number of pregnancies and births,similar age,course of disease and body mass index) and control group (36 cases treated with nilestriol) for 3 months.The Kupperman score,efficacy and adverse reactions of the two groups before and after treatment were evaluated and compared. Results Five cases were excluded and 93.06% (67/72) of the subjects completed the study.Kupperman score of symptoms and total scores:before treatment,the two groups were equal (P>0.05);except for urinary symptoms,the two groups were lower than before treatment (P<0.05);after treatment,insomnia,fatigue,fatigue and total scores of the observation group were lower than those of the control group (P<0.05),and the other symptoms of the two groups were close (P>0.05).The total effective rate of the observation group was 96.97% (32/33),higher than 79.41% (27/34) of the control group,but there was no significant difference between two groups(P>0.05).The adverse reaction rate of the observation group was lower than that of the control group,but there was no significant difference between two groups［6.06% (2/33) vs 20.59% (7/34),P>0.01］. Conclusion It is effective and safe to treat female climacteric syndrome with Kanli Jiaotai decoction combined with heart and kidney channel manipulation.